Balwinder S Bhatti

US Patent:

6337351, Jan 8, 2002

Filed:

Sep 8, 1999

Appl. No.:

09/391747

Inventors:

Gary Maurice Dull - Lewisville NC
Jared Miller Wagner - Stillwater OK
William Scott Caldwell - Winston-Salem NC
Craig Harrison Miller - Winston-Salem NC
Jeffrey Daniel Schmitt - Winston-Salem NC
Balwinder Singh Bhatti - Winston-Salem NC
Srishailkumar Basawannappa Hadimani - Winston-Salem NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A01N 3302

US Classification:

514649, 514654, 564336, 564374, 564383

Abstract:

Pharmaceutical compositions aryl substituted amine compounds, and in particular, 3-aminophenyl amine compounds are provided. Representative compounds are (4E)-N-methyl-5-(3-acetamido-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-amino-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-(dimethylamino)phenyl)-4-penten-2-amine, (4E)-N-methyl-5-(4-methyl-3-nitrophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-fluorophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3,4-dichlorophenyl)-4-penten-2-amine and (4E)-N-methyl-5-(3,4-methylenedioxyphenyl)-4-penten-2-amine.

US Patent:

6417359, Jul 9, 2002

Filed:

Apr 27, 2000

Appl. No.:

09/560421

Inventors:

Peter Anthony Crooks - Lexington KY
Haeil Park - Kangwon-do, KR
Balwinder Singh Bhatti - Winston-Salem NC
William Scott Caldwell - Winston-Salem NC
Gary Maurice Dull - Lewisville NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D40104

US Classification:

544298, 544299, 544309, 544317, 544323, 544326, 544330, 544332

Abstract:

A compound having the formula: wherein Xâ is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0, but not equal to 0; A, Aâ and Aâ are individually substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; Zâ is a substituent other than hydrogen; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Zâ is hydrogen or a substituent other than hydrogen; Y is C O, C(OH)Râ or CâA, where Râ is hydrogen or lower alkyl.

US Patent:

6455554, Sep 24, 2002

Filed:

May 12, 2000

Appl. No.:

09/570226

Inventors:

Gary Maurice Dull - Lewisville NC
Craig Harrison Miller - Winston-Salem NC
William Scott Caldwell - Winston-Salem NC
Dwo Lynm - Winston-Salem NC
Balwinder Singh Bhatti - Winston-Salem NC
Jeffrey Daniel Schmitt - Winston-Salem NC
Gary Dwight Byrd - Winston-Salem NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 314412

US Classification:

514358, 514357, 546329, 546347

Abstract:

Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (2S)-(4E)-N-methyl-5-[3-(5-isopropoxy-1-oxopyridin)yl)]-4-penten-2-amine, (4E)-N-methyl-5-(3-(1-oxopyridin)yl)-4-penten-2-amine, (4E)-N-methyl-5-(3-(5-((carboxymethyl)oxy)pyridin)yl)-4-penten-2-amine and (4E)-N-methyl-5-(3-(1-oxopyridin)yl)-4-penten-2-amine.

US Patent:

6579878, Jun 17, 2003

Filed:

Jul 7, 2000

Appl. No.:

09/612467

Inventors:

Balwinder Singh Bhatti - Winston-Salem NC
Thomas Jeffrey Clark - High Point NC
Craig H. Miller - Winston-Salem NC
Jeffrey Daniel Schmitt - Winston-Salem NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D48708

US Classification:

51425201, 51425505, 514256, 514242, 514339, 514413, 544182, 544238, 544242, 544336, 5462767, 548452

Abstract:

Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the central and autonomic nervous systems can be treated using pharmaceutical compositions incorporating compounds in which an aromatic ring is bridged with an alkylene or alkylidene unit to an azabicyclic moiety.

US Patent:

6624167, Sep 23, 2003

Filed:

Aug 4, 2000

Appl. No.:

09/633156

Inventors:

Thomas Jeffrey Clark - High Point NC
Balwinder Singh Bhatti - Winston-Salem NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D47108

US Classification:

514242, 514339, 514256, 514413, 514182, 548243, 548245, 548246, 548247, 548248, 548252, 544182, 544242, 544333, 5462767

Abstract:

Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and disorders associated with dysfunction of the central and autonomic nervous systems can be treated using pharmaceutical compositions incorporating compounds in which an aromatic ring is bridged with an ethylenic or acetylenic unit to an azabicyclic moiety.

US Patent:

6624173, Sep 23, 2003

Filed:

Jun 30, 1997

Appl. No.:

08/885768

Inventors:

Peter Anthony Crooks - Lexington KY
Gary Maurice Dull - Lewisville NC
William Scott Caldwell - Winston-Salem NC
Balwinder Singh Bhatti - Winston-Salem NC
Niranjan Madhukar Deo - Cincinnati OH
Alain Ravard - Petit-Courone, FR

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 3146

US Classification:

514305, 514256, 514277, 514299, 546133, 546137

Abstract:

Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e. g. , Parkinsonism, Parkinsons Disease, Tourettes Syndrome, attention deficient disorder, or schizophrenia) are treated by administering an endo or exo form of a 1-aza-2-(3-pyridyl)bicyclo[2. 2. 1]heptane, a 1-aza-2-(3-pyridyl)bicyclo [2. 2. 2]octane, a 1-aza-2-(3-pyridyl)bicyclo[3. 2. 2]nonane, a 1-aza-7-(3-pyridyl) bicyclo[2. 2. 1]heptane, a 1-aza-3-(3-pyridyl)bicyclo[3. 2. 2]nonane, or a 1-aza-7-(3-pyridyl)bicyclo[3. 2. 2]nonane.

US Patent:

6627648, Sep 30, 2003

Filed:

Aug 13, 2001

Appl. No.:

09/928984

Inventors:

Gary Maurice Dull - Lewisville NC
Erin E. Reich - Nashville TN
Jared Miller Wagner - Stillwater OK
Balwinder Singh Bhatti - Winston-Salem NC
Michael B. Consilvio - Potomac MD

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 3144

US Classification:

514351, 514357, 546300, 546315, 546334

Abstract:

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines and arylthioalkylamines, including pyridyloxyl-alkylamines, phenoxyalkylamines, pyridylthiolalkylamines and phenylthio-alkylamines. Exemplary compounds include (2-(5-bromo(3-pyridylthio))-ethyl)methylamine, (2-(5-bromo(3-pyridylthio))isopropyl)methylamine, (2-(5-bromo(3-pyridylthio))propyl)methylamine, (3-(5-bromo(3-pyridylthio))-propyl)methylamine, 3-((3S)-3-pyrrolidinyloxy)pyridine, 3-(4-piperidinyloxy)pyridine, 3-(1-methyl-4-piperidinyloxy)pyridine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, and methyl(3-tricyclo[7. 3. 1. 05,13 ]tridec-2-yloxypropyl)amine.

US Patent:

6890935, May 10, 2005

Filed:

Apr 30, 2001

Appl. No.:

09/845526

Inventors:

Gary Maurice Dull - Lewisville NC, US
Jeffrey Daniel Schmitt - Winston-Salem NC, US
Balwinder Singh Bhatti - Winston-Salem NC, US
Craig Harrison Miller - Winston-Salem NC, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D401/06
A61K031/4433
A61P025/28

US Classification:

514305, 514318, 514343, 546133, 546187, 5462764, 5462794, 544111

Abstract:

The present invention relates to aryl olefinic azacyclic compounds and aryl acetylenic azacyclic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. The present invention also relates to prodrug derivatives of the compounds of the present invention.