Arlene Wyman Petri

US Patent:

20100227853, Sep 9, 2010

Filed:

Apr 17, 2009

Appl. No.:

12/426171

Inventors:

Charles S. Hoffman - Wenham MA, US
Frank Douglas Ivey - Watertown MA, US
Arlene Wyman Petri - Wayland MA, US

Assignee:

Trustees of Boston College - Chestnut Hill MA

International Classification:

A61K 31/55
A61K 31/519
A61P 35/02
A61P 29/00
A61P 31/18
A61P 9/10
A61P 19/10
A61P 37/06
A61K 31/5377
A61K 31/4015
A61K 31/551
A61K 31/4985

US Classification:

51421706, 5142601, 51425505, 5142342, 514424, 51425216, 514267, 51425211, 514218, 514250

Abstract:

Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositions that include such compounds. The invention, in part, also includes methods of using cAMP PDE-inhibiting compounds in the treatment of cAMP PDE-associated diseases and/or disorders.