Arabinda Guha

Author:

Arabinda Guha

ISBN #:

8172153295

US Patent:

42450519, Jan 13, 1981

Filed:

Mar 30, 1978

Appl. No.:

5/891808

Inventors:

Edward Reich - New York NY
Arabinda Guha - Pelham Manor NY
Wolf-Dieter Schleuning - New York NY

Assignee:

Rockefeller University - New York NY

International Classification:

C12N 948
A61K 3516

US Classification:

435212

Abstract:

A plasminogen proactivator and a corresponding activator has been isolated from mammalian and avian, especially human, plasma which is characterized within a given species as a single, electrophoretically and immunologically homogeneous protein. The activator acts as a catalyst to initiate fibrinolytic activity in plasma and is therefore useful in controlling clotting which occurs, e. g. in venous thrombosis or arterial occulsion, and in diagnosing conditions which predispose to thromboembolic phenomena. The proactivator has a long useful in vivo half life and can be used to provide a reservoir for maintaining the fibrolytic potential of blood.