Anthony James Lepine

US Patent:

20100203172, Aug 12, 2010

Filed:

Feb 10, 2010

Appl. No.:

12/703448

Inventors:

Craig Sherman - Scottsdale AZ, US
Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

International Classification:

A61K 33/00
A61P 9/00
A61P 11/00
A61P 31/00
C01B 21/20
G01N 33/00

US Classification:

424718, 423385, 436133

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

US Patent:

20130281702, Oct 24, 2013

Filed:

Apr 23, 2013

Appl. No.:

13/868729

Inventors:

Jonathan P. Pease - Cedarburg WI, US
Anthony J. LePine - Greendale WI, US
Catherine M. Smith - Grafton WI, US

International Classification:

C07D 211/58

US Classification:

546244

Abstract:

A method and an intermediate are provided for preparing fentanyl. Aniline and 1-phenylethyl-4-piperidone are reacted with a borane complex, in a lower C-Calcoholic solvent, in the presence of an alkanoic acid. The reaction mixture is then treated with a hydrohalic acid to precipitate 4-anilino-N-phenethyl-4-piperidine (ANPP) as the bis-hydrohalide salt in high yield and purity. This ANPP salt may be directly treated with propionyl halide to produce fentanyl, or the ANPP salt may be converted to the free base of ANPP and similarly treated with propionyl halide to produce fentanyl.

US Patent:

20140023730, Jan 23, 2014

Filed:

Oct 1, 2013

Appl. No.:

14/042783

Inventors:

Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

Assignee:

Hope Medical Enterprises, Inc. dba Hope Pharmaceuticals - Scottsdale AZ

International Classification:

A61K 33/00

US Classification:

424718

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

US Patent:

20210100833, Apr 8, 2021

Filed:

Dec 18, 2020

Appl. No.:

17/126329

Inventors:

- Scottsdale AZ, US
Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

International Classification:

A61K 33/00
C01B 21/50
A61P 17/00
A61P 9/00
A61P 43/00
A61P 11/00
A61K 31/17
A61K 31/4418
A61K 31/4709
A61K 31/519
A61K 9/08
A61K 9/00

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

US Patent:

20200237809, Jul 30, 2020

Filed:

Apr 8, 2020

Appl. No.:

16/842939

Inventors:

- Scottsdale AZ, US
Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

International Classification:

A61K 33/00
A61P 11/00
A61P 43/00
A61P 9/00
A61P 17/00
A61K 9/00
A61K 9/08
A61K 31/519
A61K 31/4709
A61K 31/4418
A61K 31/17
C01B 21/50

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

US Patent:

20200016193, Jan 16, 2020

Filed:

Sep 23, 2019

Appl. No.:

16/578671

Inventors:

- Scottsdale AZ, US
Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

International Classification:

A61K 33/00
A61K 9/00
A61K 9/08
A61K 31/519
A61K 31/4709
A61K 31/4418
A61K 31/17
C01B 21/50

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

US Patent:

20180256638, Sep 13, 2018

Filed:

May 8, 2018

Appl. No.:

15/973659

Inventors:

- Scottsdale AZ, US
Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

International Classification:

A61K 33/00
A61K 31/4709
A61K 9/08
A61K 31/519
A61K 31/4418
A61K 31/17
C01B 21/50
A61K 9/00

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

US Patent:

20170252368, Sep 7, 2017

Filed:

May 19, 2017

Appl. No.:

15/599617

Inventors:

- Scottsdale AZ, US
Anthony James Lepine - Greendale WI, US
Catherine Marie Smith - Grafton WI, US
Kevin Robert Wirtz - Belgium WI, US
Erich Schulze - Mission Viejo CA, US

International Classification:

A61K 33/00
A61K 31/17
A61K 31/4709
A61K 9/00
A61K 31/519
A61K 9/08
C01B 21/50
A61K 31/4418

Abstract:

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.