Anthony Patrick Caggiano

US Patent:

7485295, Feb 3, 2009

Filed:

Sep 26, 2006

Appl. No.:

11/527318

Inventors:

Anthony O. Caggiano - Larchmont NY, US
Jennifer Iaci - Montville NY, US
Andrea Vecchione - Mt. Vernon NY, US
Elizabeth Markensohn - Flanders NJ, US

Assignee:

Acorda Therapeutics, Inc. - Hawthorne NY

International Classification:

A61K 38/47
A61K 38/46
C12N 9/24
C07H 21/04

US Classification:

424 9461, 424 9462, 435200, 536 232

Abstract:

One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

US Patent:

7722864, May 25, 2010

Filed:

Oct 10, 2007

Appl. No.:

11/870350

Inventors:

Anthony O. Caggiano - Larchmont NY, US
Andrea Vecchione - Mt. Vernon NY, US
Jennifer Iaci - Boonton NJ, US

Assignee:

Acorda Therapeutics, Inc. - Hawthorne NY

International Classification:

A61K 38/00
A61K 38/46
C12N 9/88
C12N 9/24
C12Q 1/34
C07H 21/04

US Classification:

424 945, 424 9462, 435232, 435200, 435 8, 536 232

Abstract:

The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

US Patent:

7731956, Jun 8, 2010

Filed:

Dec 18, 2008

Appl. No.:

12/338207

Inventors:

Anthony O. Caggiano - Larchmont NY, US
Jennifer Iaci - Boonton NJ, US
Andrea Vecchione - Mt. Vernon NY, US
Elizabeth Markensohn - Flanders NJ, US

Assignee:

Acorda Therapeutics, Inc. - Hawthorne NY

International Classification:

A61K 38/00
A61K 38/46
C12N 9/88
C12N 9/24
C12Q 1/34
C07H 21/04

US Classification:

424 945, 424 9462, 435232, 435200, 435 18, 536 232

Abstract:

One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

US Patent:

8226941, Jul 24, 2012

Filed:

May 18, 2005

Appl. No.:

11/568831

Inventors:

Anthony O. Caggiano - Larchmont NY, US
Elliott A. Gruskin - Killington CT, US
Yelena G. Sheptovitsky - Stamford CT, US
Sarah Kasperbauer - Cortlandt Manor NY, US

Assignee:

Acorda Therapeutics, Inc. - Hawthorne NY

International Classification:

A61K 38/46
A61K 38/47
C12N 9/24
C07H 21/04

US Classification:

424 9462, 424 946, 424 9461, 435200, 536 232

Abstract:

An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.

US Patent:

8236302, Aug 7, 2012

Filed:

Jun 4, 2010

Appl. No.:

12/757006

Inventors:

Anthony O. Caggiano - Larchmont NY, US
Jennifer Iaci - Boonton NJ, US
Andrea Vecchione - Mt. Vernon NY, US
Elizabeth Markensohn - Flanders NJ, US

Assignee:

Acorda Therapeutics, Inc. - Ardsley NY

International Classification:

A61K 38/00
A61K 38/46
C12N 9/88
C12N 9/24
C12Q 1/34
C07H 21/04
C07K 1/00

US Classification:

424 945, 424 9462, 435232, 435200, 435 18, 536 232, 530350

Abstract:

One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

US Patent:

8404232, Mar 26, 2013

Filed:

May 17, 2010

Appl. No.:

12/781762

Inventors:

Anthony O. Caggiano - Larchmont NY, US
Andrea Vecchione - Mt. Vernon NY, US
Jennifer Iaci - Boonton NJ, US

Assignee:

Acorda Therapeutics, Inc. - Ardsley NY

International Classification:

A61K 38/00
A61K 38/46
C12N 9/88
C07H 21/04
C07K 1/00
A61M 37/00

US Classification:

424 945, 424 9462, 435232, 536 232, 530350, 604 401

Abstract:

The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

US Patent:

8410050, Apr 2, 2013

Filed:

Mar 2, 2009

Appl. No.:

12/380760

Inventors:

Haesun Kim - Teaneck NJ, US
Anthony O. Caggiano - Larchmont NY, US

Assignee:

Acorda Therapeutics, Inc. - Ardsley NY

International Classification:

A61K 38/18

US Classification:

514 76

Abstract:

The present invention relates to administering glial growth factor 2 (GGF2) to a patient in need thereof, to achieve serum levels of GGF2 within a desired therapeutic window determined based on the disease or disorder afflicting the patient. In a particular embodiment, the patient is suffering from a disease or disorder associated with reduced levels of myelination and the GGF2 is administered to promote myelination in the patient.

US Patent:

20030120566, Jun 26, 2003

Filed:

Dec 20, 2001

Appl. No.:

10/022510

Inventors:

Mark Lipschutz - Howard Beach NY, US
Anthony Caggiano - Chatham NJ, US

Assignee:

UBS PaineWebber Inc. - Weehawken NJ

International Classification:

G06F017/60

US Classification:

705/030000, 705/036000

Abstract:

In accordance with at least one embodiment of the invention, an interest determination system is provided that may perform daily calculation of account interest, with a single monthly processing of associated charges to clients.