Anthony M Caggiano

US Patent:

7959914, Jun 14, 2011

Filed:

May 17, 2004

Appl. No.:

10/847636

Inventors:

Elliott A. Gruskin - Killingworth CT, US
Jack L. Tseng - Stormville NY, US
Anthony O. Caggiano - Larchmont NY, US

Assignee:

Acorda Therapeutics, Inc. - Hawthorne NY

International Classification:

A61K 38/43
A61K 38/51

US Classification:

424 9461, 424 945, 424 941, 435232

Abstract:

A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.

US Patent:

7968089, Jun 28, 2011

Filed:

Jul 3, 2008

Appl. No.:

12/167573

Inventors:

Elliott A. Gruskin - Killingworth CT, US
Anthony O. Caggiano - Larchmont NY, US
Gargi Roy - Danbury CT, US
Rohini D'Souza - Croton on Hudson NY, US

Assignee:

Acorda Therapeutics, Inc. - Hawthorne NY

International Classification:

A61K 38/51
C12N 15/60
C12N 9/88

US Classification:

424 945, 435232, 536 232

Abstract:

The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.

US Patent:

20060233782, Oct 19, 2006

Filed:

May 17, 2004

Appl. No.:

10/848561

Inventors:

Elliott Gruskin - Killingworth CT, US
Rohini D'Souza - Croton on Hudson NY, US
Gargi Roy - Danbury CT, US
Anthony Caggiano - Larchmont NY, US

International Classification:

A61K 38/47
A61K 35/30
C07H 21/04
C12P 21/06
C12N 9/24
C12N 15/06

US Classification:

424094610, 536023200, 435200000, 435325000, 435320100, 435069100

Abstract:

The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.

US Patent:

20080025963, Jan 31, 2008

Filed:

May 17, 2004

Appl. No.:

10/847540

Inventors:

Elliott Gruskin - Killingworth CT, US
Anthony Caggiano - Larchmont NY, US
Michael Zimber - Mamroneck NY, US
Andrew Blight - Mahopac NY, US

International Classification:

A61K 38/46
A61P 25/00

US Classification:

424094600

Abstract:

The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like.

US Patent:

20090028829, Jan 29, 2009

Filed:

May 17, 2004

Appl. No.:

10/848564

Inventors:

Elliott A. Gruskin - Killingworth CT, US
Anthony O. Caggiano - Larchmont NY, US
Gargi Roy - Danbury CT, US
Jennifer Iaci - Montville NJ, US
Michael P. Zimber - Mamroneck NY, US

International Classification:

A61K 35/12
A61K 38/47
A61K 38/02
A61P 25/00

US Classification:

424 937, 424 9461, 424 9462

Abstract:

This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.

US Patent:

20110250631, Oct 13, 2011

Filed:

May 20, 2011

Appl. No.:

13/112985

Inventors:

Elliott A. GRUSKIN - Killingworth CT, US
Rohini D'SOUZA - Croton on Hudson NY, US
Gargi ROY - Danbury CT, US
Anthony G. Caggiano - Larchmont NY, US

International Classification:

C12Q 1/02
C12N 9/26
C12N 5/071
C12N 9/24
C07H 21/00
C12N 15/63

US Classification:

435 29, 536 232, 4353201, 435325, 435200, 435201

Abstract:

The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.

US Patent:

20110262413, Oct 27, 2011

Filed:

May 9, 2011

Appl. No.:

13/103347

Inventors:

Elliott A. GRUSKIN - Killingworth CT, US
Jack L. TSENG - Stormville NY, US
Anthony O. CAGGIANO - Larchmont NY, US

International Classification:

A61K 35/14
A61P 29/00

US Classification:

424 9371, 424 937

Abstract:

A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.