150 S Huntington Ave, Boston, MA 02130 617 232-9500 (Phone), 617 232-9500 (Fax)
Certifications:
Internal Medicine, 1994
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School Stanford University Graduated: 1990 Medical School Brigham and Womens Hospital Graduated: 1990 Medical School Dana-Farber Cancer Institute Graduated: 1990
Charles Zacharchuk - Westford MA, US Susan Quinn - Norwood MA, US Patricia Martins - Somerville MA, US Lee Greenberger - Montclair NJ, US Ante Lundberg - Newton MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/47
US Classification:
514313000
Abstract:
This invention discloses method of treating or inhibiting cancer in a human having at least one of an Exon 19 del E746-A750 and/or an Exon 21 point mutation comprising administering to said human gefitinib and/or iressa alone or in combination with other cytotoxic agents or chemotherapeutic agents and an effective amount of EGFR kinase inhibitor.
Materials And Methods For Treatment Of Hemoglobinopathies
- Boston MA, US Ante Sven Lundberg - Cambridge MA, US Tirtha Chakraborty - Cambridge MA, US Michelle I-Ching Lin - Cambridge MA, US Bibhu Prasad Mishra - Wakefield MA, US Elizabeth Paik - Cambridge MA, US Andrew Kernytsky - Cambridge MA, US Todd Douglass Borland - Cambridge MA, US
Materials and methods for treating a patient with a hemoglobinopathy, both ex vivo and in vivo, and materials and methods for deleting, modulating, or inactivating a transcriptional control sequence of a BCL11A gene in a cell by genome editing.
Materials And Methods For Treatment Of Amyotrophic Lateral Sclerosis And/Or Frontal Temporal Lobular Degeneration
The present application provides materials and methods for treating a patient with Amyotrophic Lateral Sclerosis (ALS) and/or Frontaltemporal Lobular Degeneration (FTLD), both ex vivo and in vivo. In addition, the present application provides materials and methods for editing to modulate the expression, function or activity of the C9ORF72 gene in a cell by genome editing.
Crispr-Cas9 Modified Cd34+ Human Hematopoietic Stem And Progenitor Cells And Uses Thereof
- Boston MA, US Tirtha Chakraborty - Cambridge MA, US Ante Sven Lundberg - Cambridge MA, US Tony Ho - Cambridge MA, US Laura Sandler - Cambridge MA, US Brenda Eustace - Boston MA, US Jerome Rossert - Boston MA, US Robert Kauffman - Boston MA, US
Provided herein, in some embodiments, are methods and compositions for treatment of subjects with β-thalassemia and subjects with severe sickle cell disease using autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells.
Materials And Methods For Treatment Of Hemoglobinopathies
- Zug, CH Ante Sven Lundberg - Cambridge MA, US Tirtha Chakraborty - Cambridge MA, US Michelle l-ching Lin - Cambridge MA, US Bibhu Prasad Mishra - Cambridge MA, US Elizabeth Jae-eun Paik - Cambridge MA, US Andrew Kernytsky - Cambridge MA, US Todd Douglass Borland - Cambridge MA, US
Assignee:
CRISPR Therapeutics AG - Zug
International Classification:
A61K 48/00 C12N 9/22 C12N 15/10
Abstract:
Materials and methods for treating a patient with a hemoglobinopathy, both ex vivo and in vivo, and materials and methods for deleting, modulating, or inactivating a transcriptional control sequence of a BCL11A gene in a cell by genome editing.
Materials And Methods For Treatment Of Glycogen Storage Disease Type 1A
- Basel, CH Roman Lvovitch BOGORAD - Cambridge MA, US Ante Sven LUNDBERG - Cambridge MA, US Kirsten Leah BEAUDRY - Cambridge MA, US
International Classification:
C12N 15/90 C12N 9/22 C12N 9/16 C12N 15/11
Abstract:
The present application provides materials and methods for treating a patient with Glycogen Storage Disease type la (GSD1a) both ex vivo and in vivo. In addition, the present application provides materials and methods for modulating the expression, function, and/or activity of the glucose-6-phosphatase, catalytic (G6PC) and/or the glucose-6-phosphatase (G6Pase) protein in a cell by genome editing.
Materials And Methods For Treatment Of Duchenne Muscular Dystrophy
The present application provides materials and methods for treating a patient with Duchenne Muscular Dystrophy (DMD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing a dystrophin gene in a cell by genome editing.
Materials And Methods For Treatment Of Hemoglobinopathies
- Zug, CH Ante Sven Lundberg - Cambridge MA, US Tirtha Chakraborty - Cambridge MA, US Michelle I-ching Lin - Cambridge MA, US Bibhu Prasad Mishra - Cambridge MA, US Elizabeth Jae-eun Paik - Cambridge MA, US Andrew Kernytsky - Cambridge MA, US Todd Douglas Borland - Cambridge MA, US
Assignee:
CRISPR Therapeutics AG - Zug
International Classification:
A61K 48/00 A61K 31/395 A61P 7/00
Abstract:
Materials and methods for treating a patient with a hemoglobinopathy, both ex vivo and in vivo, and materials and methods for deleting, modulating, or inactivating a transcriptional control sequence of a BCL11A gene in a cell by genome editing.
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