Anna E Maciag

US Patent:

20120238518, Sep 20, 2012

Filed:

Nov 12, 2010

Appl. No.:

13/509431

Inventors:

Anna E. Maciag - Frederick MD, US
Larry K. Keefer - Bethesda MD, US
Joseph E. Saavedra - Thurmont MD, US
Lucy M. Anderson - Catonsville MD, US
Harinath Chakrapani - Pashan Pune, IN

Assignee:

The United States of America, as represented by the Secretary, Dept of Health and Human Services - Bethesda MD

International Classification:

A61K 31/551
C07D 243/08
A61K 31/704
A61P 35/00
A61K 31/69
A61K 31/495
C07D 295/30

US Classification:

514 34, 514218, 51425501, 540575, 544382, 514 64

Abstract:

Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (NO-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.

US Patent:

20200247762, Aug 6, 2020

Filed:

Apr 20, 2018

Appl. No.:

16/605643

Inventors:

- Oakland CA, US
- Frederick MD, US
David TURNER - Frederick MD, US
Anna E. MACIAG - Frederick MD, US
Marcin DYBA - Frederick MD, US
Elizabeth D. VO - San Francisco CA, US
Joseph SAAVEDRA - Thurmont MD, US
Vandana KUMARI - Frederick MD, US

International Classification:

C07D 251/24
C07D 405/12
C07D 307/33
C07D 303/46
C07D 305/06
C07C 233/11
C07D 307/06
C07D 307/36
C07D 239/26
C07D 241/12
C07D 213/40
C07D 237/08
C07C 233/31
C07D 207/40
C07D 231/56
C07D 409/12
C07D 403/06
C07D 401/06
C07D 403/14
C07D 405/14
C07D 471/04
C07D 487/04

Abstract:

Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.

US Patent:

20180289683, Oct 11, 2018

Filed:

May 6, 2016

Appl. No.:

15/571475

Inventors:

- Oakland CA, US
- Frederick MD, US
David TURNER - San Francisco CA, US
Stephan GYSIN - Basel, CH
Anna E. MACIAG - Frederick MD, US
Oleg CHERTOV - Frederick MD, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
LEIDOS BIOMEDICAL RESEARCH, INC. - Frederick MD

International Classification:

A61K 31/445
A61P 35/00
C07D 211/60

Abstract:

Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.