Peter M. Wovkulich - Nutley NJ Milan R. Uskokovic - Upper Montclair NJ Ann Goldstein - Upper Montclair NJ John A. McLane - West Haven CT
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 31365 C07D30910
US Classification:
514460
Abstract:
The invention relates to compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or methyl; A is ##STR2## or A is ##STR3## wherein R. sub. 2 is lower alkyl; R. sub. 3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R. sub. 4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR4## wherein A is ##STR5## or A is ##STR6## and R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are as described above; or a pharmaceutically acceptable salt of said acid, a C. sub. 1-4 alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha. -monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.
Peter M. Wovkulich - Nutley NJ Milan R. Uskokovic - Upper Montclair NJ Ann Goldstein - Upper Montclair NJ John A. McLane - West Haven CT
Assignee:
Hoffman-La Roche Inc. - Nutley NJ
International Classification:
C07C 6976 C07C 6963
US Classification:
560 61
Abstract:
The invention relates to compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or methyl; ##STR2## wherein R. sub. 2 is lower alkyl; R. sub. 3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R. sub. 4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR3## and R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are as described above; or a pharmaceutically acceptable salt of said acid, a C. sub. 1-4 alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha. -monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.
Unlike Jhumpa Lahiri, who became so captivated by Italian she used it to write In Other Words (and hired Ann Goldstein for the English translation), Collins's goals for learning French were more modest: "I wanted to speak French and to sound like North Carolina." She also wanted to be able to deal w
Date: Sep 15, 2016
Category: Health
Source: Google
Los Angeles museum parts ways with 'savaged' director Jeffrey Deitch
The downtown institution acquired a reputation for a revolving door amid the exodus of senior staff such as Philipp Kaiser, Ann Goldstein and, most damagingly, Paul Schimmel, the chief curator, who fell out with the director.
Date: Jul 24, 2013
Category: Entertainment
Source: Google
It's Official: Jeffrey Deitch Out as MOCA Director
the first major museum survey of street art, proved itself a populist hit, drawing record numbers for the museum, despite continued grumblings from critics that street art wasnt the rigorous academic exhibition that they were used to from the shows curated by Paul Schimmel and Ann Goldstein under Stric
Date: Jul 24, 2013
Category: Entertainment
Source: Google
Barclays Center announces inagural art commissions
seum Amsterdam will reaffirm and strengthen its place among leading international art institutions, cast light on todays Amsterdam as a center of artistic experimentation and bring new life to the Museumplein, one of the worlds most important cultural landscapes, Stedelijk Director Ann Goldstein staAlso on view at the time of the opening is a temporary exhibition of large-scale works and installations from the permanent collection, organized by Ann Goldstein with Stedelijk curators Leontine Coelewij and Bart Rutten. Works in Place is the first exhibition to occupy the distinctive 1,092-square- the most courageous, protean and provocative artists of our time, and is the largest overview of his work to date. The exhibition is organized by Stedelijk Museum Director Ann Goldstein, in cooperation with the Kelley Studio, the Estate of Mike Kelley, and the Mike Kelley Foundation for the Arts. T
Date: Sep 21, 2012
Category: Sports
Source: Google
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