Anindita Bhoumik

US Patent:

7888355, Feb 15, 2011

Filed:

Aug 11, 2010

Appl. No.:

12/854730

Inventors:

Anindita Bhoumik - San Diego CA, US
Nicholas D. P. Cosford - San Diego CA, US
Russell Dahl - Carlsbad CA, US

Assignee:

Burnham Institute for Medical Research - La Jolla CA

International Classification:

A61K 31/40
A61K 31/4406
A61K 31/215
A61K 31/165
A61K 31/16
A61K 31/5375
A61K 31/495
C07D 265/30
C07D 241/04
C07D 211/00
C07D 207/04

US Classification:

5142375, 51425501, 514357, 514423, 514510, 514623, 544106, 544380, 546285, 548528, 560302, 564123

Abstract:

There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.

US Patent:

20090054438, Feb 26, 2009

Filed:

Aug 15, 2008

Appl. No.:

12/192753

Inventors:

Ze'ev A. Ronai - San Diego CA, US
Anindita Bhoumik - San Diego CA, US
Nicholas D.P. Cosford - San Diego CA, US
Russell Dahl - Carlsbad CA, US

Assignee:

Burnham Institute for Medical Research - La Jolla CA

International Classification:

A61K 31/5375
C07C 233/57
C07D 213/02
C07D 207/04
C07D 265/30
C07D 241/04
A61K 31/215
A61K 31/352
A61P 35/00
C12N 5/00
A61K 31/495
C07C 69/76
A61K 31/164
A61K 31/44
A61K 31/40

US Classification:

5142375, 564188, 546285, 548528, 544154, 544380, 560 51, 514623, 514357, 514423, 51425501, 514529, 435375, 514450

Abstract:

There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.

US Patent:

20090281025, Nov 12, 2009

Filed:

Oct 17, 2005

Appl. No.:

11/577489

Inventors:

Anindita Bhoumik - San Diego CA, US
Ze'ev Ronai - San Diego CA, US

Assignee:

Mount Sinai School Of Medicine of New York University - New York NY

International Classification:

A61K 38/16
C12N 5/00
C07H 21/00
C12N 15/74
A61P 35/00

US Classification:

514 12, 435375, 536 2372, 4353201

Abstract:

The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies, such as radiation therapy, chemotherapy, or a combinations thereof. The invention provides methods for identifying and implementing strategies to inhibit a transcription factor involved in promoting resistance and inhibition of apoptosis. The invention provides a compound that alters ATF2 activity, specifically amino-terminal fragments of ATF2 that retain the JNK binding domain. The invention provides methods for inhibiting tumor cell growth and for sensitizing tumor cells to apoptosis with such peptides.

US Patent:

20110129844, Jun 2, 2011

Filed:

Dec 19, 2008

Appl. No.:

12/810008

Inventors:

Ze'ev Ronai - La Jolla CA, US
Anindita Bhoumik - La Jolla CA, US

International Classification:

C12Q 1/68

US Classification:

435 614

Abstract:

The present invention is based on the discovery of the tumor suppressor role of activating transcription factor 2 (ATF2) in non-melanoma skin cancer development. Accordingly, the invention provides methods of diagnosing a subject as having or at risk of having skin cancer. Also provided are methods of treating skin cancer in a subject, characterizing skin cancer in a subject, and identifying agents useful for treating skin cancer in a subject.

US Patent:

20110166216, Jul 7, 2011

Filed:

Feb 4, 2011

Appl. No.:

13/021548

Inventors:

Ze'ev A. Ronai - San Diego CA, US
Anindita Bhoumik - San Diego CA, US
Nicholas D. P. Cosford - San Diego CA, US
Russell Dahl - Carlsbad CA, US

International Classification:

A61K 31/352
C12N 5/02
A61P 35/04

US Classification:

514453, 435375

Abstract:

There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.