Anil G Cashikar

US Patent:

20090099069, Apr 16, 2009

Filed:

Dec 1, 2005

Appl. No.:

11/720586

Inventors:

Susan L. Lindquist - Chestnut Hill MA, US
Aaron D. Gitler - Philadelphia PA, US
Anil Cashikar - Martinez GA, US
Antony A. Cooper - Kansas City MO, US
Cole M. Haynes - New York NY, US

Assignee:

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH - Cambridge MA
THE CURATORS OF THE UNIVERSITY MISSOURI - Columbia MO

International Classification:

A61K 38/16
A61K 31/7052
C12N 5/00
C12Q 1/02
A61P 25/00
C12N 1/19
G01N 33/68
C07H 21/00

US Classification:

514 12, 514 44, 435375, 435 29, 436 86, 536 241, 4352542, 435325

Abstract:

Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.

US Patent:

20130244903, Sep 19, 2013

Filed:

Jan 18, 2013

Appl. No.:

13/745052

Inventors:

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH - , US
THE CURATORS OF THE UNIVERSITY OF MISSOURI - , US
Anil Cashikar - Martinez GA, US
Antony A. Cooper - Kansas City MO, US
Cole M. Haynes - New York NY, US

Assignee:

THE CURATORS OF THE UNIVERSITY OF MISSOURI - Columbia MO
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

506 10, 435 612, 4352542, 435325

Abstract:

Disclosed are compositions and methods for modulating expression of genes that function at the step of ER to Golgi trafficking. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.

US Patent:

20160046933, Feb 18, 2016

Filed:

Mar 24, 2015

Appl. No.:

14/666517

Inventors:

- Cambridge MA, US
Aaron D. Gitler - Foster City CA, US
Anil Cashikar - Martinez GA, US

International Classification:

C12N 15/113
C12N 15/10

Abstract:

Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.