Andrew A Price

US Patent:

7947510, May 24, 2011

Filed:

Aug 1, 2008

Appl. No.:

12/185008

Inventors:

Daniel K. Schwartz - Boulder CO, US
Andrew D. Price - Nederland CO, US

Assignee:

The Regents of the University of Colorado, a body corporate - Denver CO

International Classification:

G01N 21/00

US Classification:

436164, 436 94, 4352871, 349 56, 349 61, 349167, 349199

Abstract:

The present invention provides novel methods and devices for detecting hybridization of nucleic acids using liquid crystals and cationic surfactants.

US Patent:

20220364150, Nov 17, 2022

Filed:

Jul 11, 2022

Appl. No.:

17/861503

Inventors:

- Pleasanton CA, US
Shalini GOHIL - Castro Valley CA, US
Christopher HINDSON - Livermore CA, US
Adam LOWE - Mountain House CA, US
Andrew D. PRICE - Hayward CA, US
Joseph Francis SHUGA - Pleasanton CA, US

Assignee:

10x Genomics, Inc. - Pleasanton CA

International Classification:

C12Q 1/6806
B01J 13/18
B01J 13/00
C08J 3/075

Abstract:

The present disclosure provides systems and methods for making a hydrogel comprising a cell, cell nucleus, or one or more components derived from a cell or cell nucleus. A method for making a hydrogel may comprise providing a cell or cell nucleus, a first polymer, wherein the first polymer comprises a plurality of first crosslink precursors, each of the plurality of first crosslink precursors comprising an azide group; providing a second polymer, wherein the second polymer comprises a plurality of second crosslink precursors, each of the plurality of second crosslink precursors comprising an alkyne group; and crosslinking the first polymer and the second polymer via a reaction between a first section of the first crosslink precursors and a second section of the second crosslink precursors, thereby providing the hydrogel comprising the cell or cell nucleus.

US Patent:

20220228201, Jul 21, 2022

Filed:

Dec 29, 2021

Appl. No.:

17/565028

Inventors:

- Pleasanton CA, US
David Michael PATTERSON - Oakland CA, US
Andrew D. PRICE - San Diego CA, US
Eswar Prasad RAMACHANDRAN IYER - Sunnyvale CA, US

International Classification:

C12Q 1/6837
C12Q 1/6869

Abstract:

Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate. Compositions such as nucleic acid arrays produced by the methods are also disclosed. In some embodiments, provided herein is photocontrollable hybridization, where oligonucleotides with photo-caged bases prevent hybridization of complementary nucleic acid strands. Uncaging of the oligonucleotides allows hybridization and/or ligation of nucleic acid molecules at the exposed area. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.

US Patent:

20230063675, Mar 2, 2023

Filed:

Oct 31, 2022

Appl. No.:

17/978130

Inventors:

- San Diego CA, US
Tarun Kumar Khurana - Fremont CA, US
Liangliang Qiang - San Diego CA, US
Andrew J. Price - San Mateo CA, US
Elisabet Rosas - El Cerrito CA, US

International Classification:

C12Q 1/6874
C12N 15/10

Abstract:

An example of a sequencing kit includes a flow cell and an encapsulation matrix precursor composition. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid and a polymer selected from the group consisting of agar, agarose, alginate, heparin, alginate sulfate, dextran sulfate, hyaluronan, pectin, carrageenan, gelatin, chitosan, cellulose, a collagen polymer, and combinations thereof.

US Patent:

20210372998, Dec 2, 2021

Filed:

Mar 22, 2021

Appl. No.:

17/209045

Inventors:

- Pleasanton CA, US
Jason Bell - Palo Alto CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Christopher Hindson - Livermore CA, US
Bill Kengli Lin - Pleasanton CA, US
Anthony Makarewicz - Livermore CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Francesca Meschi - Menlo Park CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Pleasanton CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Sarah Taylor - Fremont CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Yifeng Yin - Elk Grove CA, US
Xinying Zheng - San Jose CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Eswar Prasad Ramachandran Iyer - Sunnyvale CA, US
Luigi Jhon Alvarado Martinez - Pleasanton CA, US

International Classification:

G01N 33/532
C07K 14/74
C12N 15/85
G01N 33/543
G01N 33/548
C12N 15/10
C12Q 1/6804
C12Q 1/6806
G01N 33/50
G01N 33/53
G01N 33/58
C12Q 1/6818
C12Q 1/6827
C12Q 1/6881
C12N 15/11
G01N 33/569

Abstract:

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.

US Patent:

20210102936, Apr 8, 2021

Filed:

Jun 9, 2020

Appl. No.:

16/897126

Inventors:

- Pleasanton CA, US
Jason Bell - Palo Alto CA, US
Zachary Bent - Pleasanton CA, US
Rajiv Bharadwaj - Pleasanton CA, US
Christopher Hindson - Livermore CA, US
Bill Lin - Pleasanton CA, US
Anthony Makarewicz - Livermore CA, US
Geoffrey McDermott - Livermore CA, US
Elliott Meer - Pleasanton CA, US
Francesca Meschi - Menlo Park CA, US
Tarjei Sigurd Mikkelsen - Dublin CA, US
Christopher Joachim O'Keeffe - Pleasanton CA, US
Katherine Pfeiffer - Berkeley CA, US
Andrew D. Price - Hayward CA, US
Paul Ryvkin - San Jose CA, US
Sarah Taylor - Fremont CA, US
Jessica Michele Terry - Pleasanton CA, US
Tobias Daniel Wheeler - Alameda CA, US
Yifeng Yin - Elk Grove CA, US
Xinying Zheng - San Jose CA, US
Solongo Batjargal Ziraldo - San Ramon CA, US
Eswar Prasad Ramachandran Iyer - Sunnyvale CA, US
Luigi Jhon Alvarado Martinez - Pleasanton CA, US

International Classification:

G01N 33/532
C07K 14/74
C12N 15/85
G01N 33/543
G01N 33/548
C12N 15/10
C12Q 1/6804
C12Q 1/6806
G01N 33/50
G01N 33/53
G01N 33/58
C12Q 1/6818
C12Q 1/6827
C12Q 1/6881
C12N 15/11
G01N 33/569

Abstract:

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins) and chromatin (e.g., accessible chromatin).

US Patent:

20200392564, Dec 17, 2020

Filed:

Sep 1, 2020

Appl. No.:

17/009352

Inventors:

- Pleasanton CA, US
Shalini GOHIL - Castro Valley CA, US
Christopher HINDSON - Livermore CA, US
Adam LOWE - Mountain House CA, US
Andrew D. PRICE - Hayward CA, US
Joseph Francis SHUGA - Pleasanton CA, US

Assignee:

10X Genomics, Inc. - Pleasanton CA

International Classification:

C12Q 1/6806
B01J 13/18
B01J 13/00
C08J 3/075

Abstract:

The present disclosure provides systems and methods for making a hydrogel comprising a cell, cell nucleus, or one or more components derived from a cell or cell nucleus. A method for making a hydrogel may comprise providing a cell or cell nucleus, a first polymer, wherein the first polymer comprises a plurality of first crosslink precursors, each of the plurality of first crosslink precursors comprising an azide group; providing a second polymer, wherein the second polymer comprises a plurality of second crosslink precursors, each of the plurality of second crosslink precursors comprising an alkyne group; and crosslinking the first polymer and the second polymer via a reaction between a first section of the first crosslink precursors and a second section of the second crosslink precursors, thereby providing the hydrogel comprising the cell or cell nucleus.

US Patent:

20200354771, Nov 12, 2020

Filed:

Apr 22, 2020

Appl. No.:

16/855177

Inventors:

- Pleasanton CA, US
Josephine Lee - Hayward CA, US
Francesca Meschi - Menlo Park CA, US
Luz Montesclaros - Pittsburg CA, US
Katherine Pfeiffer - Berkeley CA, US
Andrew D. Price - Hayward CA, US
Jerald Sapida - San Jose CA, US
David Sukovich - San Francisco CA, US
Tobias Daniel Wheeler - Alameda CA, US
Yifeng Yin - Elk Grove CA, US

International Classification:

C12Q 1/6806

Abstract:

The present disclosure provides methods and systems for sample preparation and/or analysis. Samples may be cells, or may be derived from one or more cells. Sample preparation may comprise conducting one or more reactions on a target. Such reactions may be conducted in one or more partitions. One or more reactions may be performed in one or more successive operations.