Andrew J Leach

US Patent:

7723120, May 25, 2010

Filed:

Oct 26, 2005

Appl. No.:

11/259643

Inventors:

Caibin Xiao - Harleysville PA, US
Radislav A. Potyrailo - Niskayuna NY, US
William G. Morris - Rexford NY, US
Scott M. Boyette - New Hope PA, US
LiJie Yu - Clifton Park NY, US
Theodore J. Cecconie - Buckingham PA, US
Andrew M. Leach - Clifton Park NY, US
Prashant V. Shrikhande - Trevose PA, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 21/00
G06K 9/38
C12Q 1/68
G01N 33/543
F16L 7/00

US Classification:

436164, 436518, 422 8205, 382273, 435 6, 137375

Abstract:

Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

US Patent:

20050153964, Jul 14, 2005

Filed:

Apr 10, 2003

Appl. No.:

10/510544

Inventors:

Andrew Leach - King of Prussia PA, US
Stephen Smith - Stevenage, GB

International Classification:

C07D413/02
C07D043/02
A61K031/5377
A61K031/513
A61K031/4545
A61K031/44

US Classification:

514235500, 514269000, 514318000, 514345000, 544122000, 544124000, 544310000, 546194000, 546300000

Abstract:

Compounds of formula (I): are inhibitors of the enzyme Lp-PLAand are of use in therapy, in particular for treating atherosclerosis. In Formula I R, R, R, R, R, R, X and Y are as defined herein.

US Patent:

20070092972, Apr 26, 2007

Filed:

Oct 26, 2005

Appl. No.:

11/259712

Inventors:

Caibin Xiao - Harleysville PA, US
Timothy Sivavec - Clifton Park NY, US
David Engel - The Woodlands TX, US
Andrew Leach - Clifton Park NY, US

International Classification:

G01N 31/22

US Classification:

436103000, 422056000

Abstract:

Embodiments of the invention provide self-contained phosphate sensors with an analyte-specific reagent and a pH-modifier. The analyte-specific reagent includes a molybdenum salt or metal complex and a dye. The self-contained phosphate sensors can be used either in aqueous or non-aqueous solution or as a solid-state device. These self-contained phosphate sensors require no post-addition reagents to determine phosphate concentrations and the phosphate determination test requires a reduced number of procedural steps. Moreover, the self-contained phosphate sensor provides enhanced sensitivity and faster response time. Embodiments of the invention also provide a method for determining phosphate concentrations in a sample. The phosphate concentration in a sample can be quantified using a calibration curve generated by testing samples with known phosphate concentrations.

Author:

Andrew Leach

ISBN #:

0748725636

Author:

Andrew Leach

ISBN #:

9056624865

Author:

Andrew Leach

ISBN #:

9076714177