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Andrea A Gambotto

age ~57

from Pittsburgh, PA

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Also known as:
  • Andrea O
Phone and address:
1250 Negley Ave, Pittsburgh, PA 15217
412 421-5518
Connected to:

Andrea Gambotto Phones & Addresses

  • 1250 Negley Ave, Pittsburgh, PA 15217 • 412 421-5518
  • North Miami, FL
  • Glenshaw, PA

Us Patents

  • Identification Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, Dna And Viruses

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  • US Patent:
    20030104622, Jun 5, 2003
  • Filed:
    Feb 13, 2002
  • Appl. No.:
    10/075869
  • Inventors:
    Paul Robbins - Mt. Lebanon PA, US
    Zhibao Mi - Pittsburgh PA, US
    Raymond Frizzell - Pittsburgh PA, US
    Joseph Glorioso - Cheswick PA, US
    Andrea Gambotto - Pittsburgh PA, US
  • International Classification:
    A61K038/08
    A61K038/10
    C07K007/06
    C07K007/08
    C12N015/85
  • US Classification:
    435/455000, 530/326000, 530/327000, 514/014000, 514/015000
  • Abstract:
    The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of such peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro. The method for identification of the internalizing peptides of the present invention comprises incubating a target cell with a peptide display library, isolating peptides with internalization characteristics and determining the ability of said peptide to internalize cargo into a cell.

  • Identification Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, Dna And Viruses

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  • US Patent:
    20030219826, Nov 27, 2003
  • Filed:
    Feb 12, 2003
  • Appl. No.:
    10/366493
  • Inventors:
    Paul Robbins - Mt. Lebanon PA, US
    Zhibao Mi - Pittsburgh PA, US
    Raymond Frizzell - Pittsburgh PA, US
    Joseph Glorioso - Cheswick PA, US
    Andrea Gambotto - Pittsburgh PA, US
    Jeffrey Mai - Pittsburgh PA, US
  • International Classification:
    G01N033/53
    C12N009/12
    C12N009/64
    C07K007/08
  • US Classification:
    435/007100, 435/194000, 435/226000, 530/328000
  • Abstract:
    The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of such peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro. The method for identification of the internalizing peptides of the present invention comprises incubating a target cell with a peptide display library, isolating peptides with internalization characteristics and determining the ability of said peptide to internalize cargo into a cell.

  • Identification Of Peptides That Facilitate Uptake And Cytoplasmic And /Or Nuclear Transport Of Proteins, Dna And Viruses

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  • US Patent:
    20050074884, Apr 7, 2005
  • Filed:
    Aug 26, 2004
  • Appl. No.:
    10/926893
  • Inventors:
    Paul Robbins - Mt. Lebanon PA, US
    Zhibao Mi - Pittsburgh PA, US
    Raymond Frizzell - Pittsburgh PA, US
    Joseph Glorioso - Cheswick PA, US
    Andrea Gambotto - Pittsburgh PA, US
  • International Classification:
    G01N033/53
    C12N015/85
    C12N015/86
    C07K007/08
    C07K007/06
  • US Classification:
    435455000, 435456000, 530327000, 530328000, 530329000, 530330000
  • Abstract:
    The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of such peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro. The method for identification of the internalizing peptides of the present invention comprises incubating a target cell with a peptide display library, isolating peptides with internalization characteristics and determining the ability of said peptide to internalize cargo into a cell.

  • Vaccines For The Rapid Response To Pandemic Avian Influenza

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  • US Patent:
    20070003576, Jan 4, 2007
  • Filed:
    Dec 9, 2005
  • Appl. No.:
    11/298102
  • Inventors:
    Andrea Gambotto - Pittsburgh PA, US
    Paul Robbins - Mt. Lebanon PA, US
    Gao Wentao - Pittsburgh PA, US
    Simon Barratt-Boyes - Pittsburgh PA, US
    Adam Soloff - Pittsburgh PA, US
  • International Classification:
    A61K 39/145
    C12N 15/861
  • US Classification:
    424209100, 435456000
  • Abstract:
    The present invention relates to adenovirus-based vaccines against avian influenza viruses with pandemic potential. The present invention provides replication-defective adenoviral vectors, each having a nucleic acid encoding an influenza A polypeptide. When introduced into a subject, the expressed influenza A polypeptide induces the production of antibodies that bind to influenza. The present invention also provides methods for inducing an immune response in a subject. Subjects are administered a replication-defective adenoviral vector, wherein the vector has a nucleic acid encoding an influenza A polypeptide. When the vector is expressed in the subject, the influenza A polypeptide induces the subject to produce antibodies to influenza.

  • Identification Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, Dna And Viruses

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  • US Patent:
    20070253968, Nov 1, 2007
  • Filed:
    Oct 27, 2006
  • Appl. No.:
    11/588479
  • Inventors:
    Paul Robbins - Mt. Lebanon PA, US
    Zhibao Mi - Pittsburgh PA, US
    Raymond Frizzell - Pittsburgh PA, US
    Joseph Glorioso - Blawnox PA, US
    Andrea Gambotto - Pittsburgh PA, US
    Jeffrey Mai - Pittsburgh PA, US
  • International Classification:
    A61K 39/00
    A61K 48/00
    C07K 14/00
    C12N 15/00
    C12N 5/06
  • US Classification:
    424184100, 424093100, 435320100, 435375000, 514002000, 530350000
  • Abstract:
    The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of such peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro. The method for identification of the internalizing peptides of the present invention comprises incubating a target cell with a peptide display library, isolating peptides with internalization characteristics and determining the ability of said peptide to internalize cargo into a cell.

  • Method Of Treating Ocular Infections

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  • US Patent:
    20080031903, Feb 7, 2008
  • Filed:
    Jul 26, 2007
  • Appl. No.:
    11/828542
  • Inventors:
    Andrea Gambotto - Pittsburgh PA, US
    Edward Nwanegbo - Pittsburgh PA, US
  • International Classification:
    A61K 39/395
    A61K 31/13
    A61K 31/135
    A61K 31/165
    A61P 31/00
    A61P 33/00
    A61K 9/00
    A61K 31/40
    A61K 31/497
  • US Classification:
    424400000, 424130100, 424133100, 424147100, 424150100, 424151100, 424152100, 424159100, 424164100, 514253060, 514412000, 514619000, 514648000, 514669000
  • Abstract:
    Provided herein are methods of preventing or treating ocular viral, fungal, protozoa or bacterial infections. The method comprises administering ocular doses of a binding agent reactive against a virus, fungus, protozoa or bacteria, which, in one embodiment, is a pooled, human immunoglobulin preparation, such as, without limitation, those suitable for intravenous use, including Gammagard or other like products. Also provided are ocular dosage forms and dosing devices comprising the binding reagent.

  • Vaccines For The Rapid Response To Pandemic Avian Influenza

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  • US Patent:
    20100008952, Jan 14, 2010
  • Filed:
    Jul 24, 2009
  • Appl. No.:
    12/509167
  • Inventors:
    Andrea Gambotto - Pittsburgh PA, US
    Paul D. Robbins - Mt. Lebanon PA, US
    Gao Wentao - Pittsburgh PA, US
    Simon Barratt-Boyes - Pittsburgh PA, US
    Adam Soloff - Pittsburgh PA, US
  • International Classification:
    A61K 39/145
    C12N 15/63
  • US Classification:
    4242091, 4353201
  • Abstract:
    The present invention relates to adenovirus-based vaccines against avian influenza viruses with pandemic potential. The present invention provides replication-defective adenoviral vectors, each having a nucleic acid encoding an influenza A polypeptide. When introduced into a subject, the expressed influenza A polypeptide induces the production of antibodies that bind to influenza.The present invention also provides methods for inducing an immune response in a subject. Subjects are administered a replication-defective adenoviral vector, wherein the vector has a nucleic acid encoding an influenza A polypeptide. When the vector is expressed in the subject, the influenza A polypeptide induces the subject to produce antibodies to influenza.

  • Identication Of Peptides That Facilitate Uptake And Cytoplasmic And/Or Nuclear Transport Of Proteins, Dna And Virues

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  • US Patent:
    6881825, Apr 19, 2005
  • Filed:
    Aug 31, 2000
  • Appl. No.:
    09/653182
  • Inventors:
    Paul D. Robbins - Mt. Lebanon PA, US
    Zhibao Mi - Pittsburgh PA, US
    Raymond Frizzell - Pittsburgh PA, US
    Joseph C. Glorioso - Cheswick PA, US
    Andrea Gambotto - Pittsburgh PA, US
  • Assignee:
    University of Pittsburgh of The Commonwealth System of Higher Education - Pittsburgh PA
  • International Classification:
    A61K038/04
    C12P021/08
  • US Classification:
    530327, 530300, 530326, 435 691, 435 697, 514 2, 514 14
  • Abstract:
    The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of the peptides, and methods of use for the peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro.

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News

'Like A Band-Aid' | News, Sports, Jobs

'Like A Band-Aid' | News, Sports, Jobs

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  • Dr. Andrea Gambotto, associate professor of surgery at the Pitt School of Medicine, said UPMC researchers had previous experience on SARS-CoV in 2003 and MERS-CoV in 2014 that taught researchers that a particular protein, called a spike protein, is important for inducing immunity against the virus.
  • Date: Apr 03, 2020
  • Category: More news
  • Source: Google
Pittsburgh Scientists Develop Possible Coronavirus Vaccine, Hope Fda Can Fast-Track It

Pittsburgh scientists develop possible coronavirus vaccine, hope FDA can fast-track it

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  • These two viruses, which are closely related to SARS-CoV-2, teach us that a particular protein, called a spike protein, is important for inducing immunity against the virus, said co-senior author Andrea Gambotto, M.D., associate professor of surgery at the Pitt School of Medicine. We knew exactly
  • Date: Apr 02, 2020
  • Category: More news
  • Source: Google

UPMC discusses potential COVID-19 vaccine

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  • in 2003 and MERS-CoV in 2014. These two viruses, which are closely related to SARS-CoV-2, teach us that a particular protein, called a spike protein, is important for inducing immunity against the virus. We knew exactly where to fight this new virus, said co-senior author Andrea Gambotto, M.D., as
  • Date: Apr 02, 2020
  • Category: More news
  • Source: Google

Doctors with Pittsburgh university announce potential coronavirus vaccine

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  • hese two viruses, which are closely related to SARS-CoV-2, teach us that a particular protein, called a spike protein, is important for inducing immunity against the virus. We knew exactly where to fight this new virus, said Dr. Andrea Gambotto, M.D., associate professor of surgery at the Pitt Scho
  • Date: Apr 02, 2020
  • Category: Health
  • Source: Google

Coronavirus In Pittsburgh: Pitt Researchers Unveil Potential COVID-19 Vaccine

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  • Back then, we didnt have the knowledge that we have now on what is needed to, to build an effective vaccine against coronaviruses in general. That was the first emerging that coronavirus, Dr. Andrea Gambotto, of the University of Pittsburgh School of Medicine, said.
  • Date: Apr 02, 2020
  • Category: Health
  • Source: Google

Tests of potential coronavirus vaccine spur growth of virus-fighting antibodies

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  • "We'd like to get this into patients as soon as possible," said Andrea Gambotto, associate professor of surgery at the University of Pittsburgh School of Medicine and co-author of a paper announcing the vaccine in the journal EBioMedicine.
  • Date: Apr 02, 2020
  • Category: Health
  • Source: Google

Killer-Flu Debate: Should Mutant H5N1 Have Been Created?

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  • "It should not have been done if the final goal is to show you can make a deadly virus," said Dr. Andrea Gambotto, an associate professor at the University of Pittsburgh, School of Medicine, and director of the university's Vector Core Facility. "In this case, the goal is different; the goal
  • Date: Dec 23, 2011
  • Category: Health
  • Source: Google
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