Ana E Gabarda

US Patent:

6921769, Jul 26, 2005

Filed:

Mar 28, 2003

Appl. No.:

10/402004

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Alexy Rivkin - New York NY, US
Ting-Chao Chou - Paramus NJ, US
Ana E. Gabarda - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K031/427
C07D272/22

US Classification:

514365, 514367, 514450, 548202, 548205, 548235

Abstract:

The present invention provides compounds of formula (I):.

US Patent:

7384964, Jun 10, 2008

Filed:

Aug 18, 2004

Appl. No.:

10/921109

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Alexey Rivkin - New York NY, US
Fumihiko Yoshimura - Kita-Ku Sapporo, JP
Ting-Chao Chou - Paramus NJ, US
Ana E. Gabarda - Boston MA, US
Huajin Dong - Beijing, CN
Kaida Wu - New York NY, US
Malcolm A. S. Moore - New York NY, US
David Dorn - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 31/428
A61K 31/427
A61K 31/422
A61K 31/423
C07D 417/04
C07D 413/04
C07D 417/06

US Classification:

514365, 514367, 514374, 514375, 548159, 548203, 548217, 548235

Abstract:

The present invention provides compounds of formula (I):.

US Patent:

7649006, Jan 19, 2010

Filed:

May 9, 2003

Appl. No.:

10/435408

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Alexey Rivkin - New York NY, US
Ting-Chao Chou - Paramus NJ, US
Ana E. Gabarda - New York NY, US
Huajin Dong - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 31/427

US Classification:

514365, 514367, 514450, 548202, 548205, 548235

Abstract:

The present invention provides compounds of formula (I):.

US Patent:

7875638, Jan 25, 2011

Filed:

Jun 9, 2008

Appl. No.:

12/135823

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Alexey Rivkin - New York NY, US
Fumihiko Yoshimura - Kita-Ku Sapporo, JP
Ting-Chao Chou - Paramus NJ, US
Ana E. Gabarda - Boston MA, US
Huajin Dong - Beijing, CN
Kaida Wu - New York NY, US
Malcolm A. S. Moore - New York NY, US
David Dorn - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 31/427
C07D 417/06

US Classification:

514365, 548204

Abstract:

The present invention provides compounds of formula (I):.

US Patent:

8110590, Feb 7, 2012

Filed:

Oct 22, 2009

Appl. No.:

12/604127

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Alexey Rivkin - New York NY, US
Ting-Chao Chou - Paramus NJ, US
Ana E. Gabarda - New York NY, US
Huajin Dong - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 31/427

US Classification:

514365

Abstract:

The present invention provides compounds of formula (I):.

US Patent:

8513429, Aug 20, 2013

Filed:

Feb 7, 2012

Appl. No.:

13/367612

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Alexey Rivkin - New York NY, US
Ting-Chao Chou - Paramus NJ, US
Ana E. Gabarda - New York NY, US
Huajin Dong - New York NY, US

Assignee:

Sloan-Kettering Insitute for Cancer Research - New York NY

International Classification:

C07D 493/04
C07D 417/06

US Classification:

548110, 548204, 549214

Abstract:

The present invention provides compounds of formula (I):.

US Patent:

20030073840, Apr 17, 2003

Filed:

Aug 27, 2001

Appl. No.:

09/940059

Inventors:

Dennis Curran - Pittsburgh PA, US
Ana Gabarda - Boston MA, US

International Classification:

C07F007/02
C07D213/62

US Classification:

546/014000, 546/298000

Abstract:

A method of synthesizing a compound having the formula: from a compound having the formula: wherein Ris hydrogen, fluorine, chlorine or SiRRR, wherein R, R, and Rare independently the same or different an alkyl group or an aryl group, Ris an alkyl group, Ris a protecting group, Ris an alkyl group, an allyl group, a propargyl group —COH, or a benzyl group, Ris —COR, wherein Ris an alkyl group or an aryl group, Xis OH and Xis H, includes the step of exposing compound (III) to at least one of an organic acid or an inorganic acid. A compound has the general formula (III).

US Patent:

20040058948, Mar 25, 2004

Filed:

Mar 3, 2003

Appl. No.:

10/378467

Inventors:

Dennis Curran - Pittsburgh PA, US
Michael Parniak - Pittsburgh PA, US
Ana Gabarda - New York NY, US

International Classification:

A61K031/4745

US Classification:

514/285000

Abstract:

A method of inhibiting retroviral reverse transcriptase or hepadnaviral reverse transcriptase includes the step of administering a pharmaceutically effective amount of a mappicine analog or a pharmaceutically acceptable salt thereof. A method of treating a patient infected with a retrovirus or hepadnavirus includes the step of administering a pharmaceutically effective amount of a mappicine analog or a pharmaceutically acceptable salt thereof