Samuel J. Danishefsky - Englewood NJ, US Alexey Rivkin - New York NY, US Fumihiko Yoshimura - Kita-Ku Sapporo, JP Ting-Chao Chou - Paramus NJ, US Ana E. Gabarda - Boston MA, US Huajin Dong - Beijing, CN Kaida Wu - New York NY, US Malcolm A. S. Moore - New York NY, US David Dorn - New York NY, US
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
Samuel J. Danishefsky - Englewood NJ, US Alexey Rivkin - New York NY, US Ting-Chao Chou - Paramus NJ, US Ana E. Gabarda - New York NY, US Huajin Dong - New York NY, US
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:
A61K 31/427
US Classification:
514365, 514367, 514450, 548202, 548205, 548235
Abstract:
The present invention provides compounds of formula (I):.
Synthesis Of Epothilones, Intermediates Thereto, Analogues And Uses Thereof
Samuel J. Danishefsky - Englewood NJ, US Alexey Rivkin - New York NY, US Fumihiko Yoshimura - Kita-Ku Sapporo, JP Ting-Chao Chou - Paramus NJ, US Ana E. Gabarda - Boston MA, US Huajin Dong - Beijing, CN Kaida Wu - New York NY, US Malcolm A. S. Moore - New York NY, US David Dorn - New York NY, US
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:
A61K 31/427 C07D 417/06
US Classification:
514365, 548204
Abstract:
The present invention provides compounds of formula (I):.
Synthesis Of Epothilones, Intermediates Thereto And Analogues Thereof
Samuel J. Danishefsky - Englewood NJ, US Alexey Rivkin - New York NY, US Ting-Chao Chou - Paramus NJ, US Ana E. Gabarda - New York NY, US Huajin Dong - New York NY, US
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:
A61K 31/427
US Classification:
514365
Abstract:
The present invention provides compounds of formula (I):.
Synthesis Of Epothilones, Intermediates Thereto And Analogues Thereof
Samuel J. Danishefsky - Englewood NJ, US Alexey Rivkin - New York NY, US Ting-Chao Chou - Paramus NJ, US Ana E. Gabarda - New York NY, US Huajin Dong - New York NY, US
Assignee:
Sloan-Kettering Insitute for Cancer Research - New York NY
International Classification:
C07D 493/04 C07D 417/06
US Classification:
548110, 548204, 549214
Abstract:
The present invention provides compounds of formula (I):.
Intermediates And Methods Of Preparation Of Intermediates In The Enantiomeric Synthesis Of (20R)Homocamptothecins And The Enantiomeric Synthesis Of (20R)Homocamptothecins
Dennis Curran - Pittsburgh PA, US Ana Gabarda - Boston MA, US
International Classification:
C07F007/02 C07D213/62
US Classification:
546/014000, 546/298000
Abstract:
A method of synthesizing a compound having the formula: from a compound having the formula: wherein Ris hydrogen, fluorine, chlorine or SiRRR, wherein R, R, and Rare independently the same or different an alkyl group or an aryl group, Ris an alkyl group, Ris a protecting group, Ris an alkyl group, an allyl group, a propargyl group —COH, or a benzyl group, Ris —COR, wherein Ris an alkyl group or an aryl group, Xis OH and Xis H, includes the step of exposing compound (III) to at least one of an organic acid or an inorganic acid. A compound has the general formula (III).
Mappicine Analogs, Methods Of Inhibiting Retroviral Reverse Transcriptase And Methods Of Treating Retroviruses
Dennis Curran - Pittsburgh PA, US Michael Parniak - Pittsburgh PA, US Ana Gabarda - New York NY, US
International Classification:
A61K031/4745
US Classification:
514/285000
Abstract:
A method of inhibiting retroviral reverse transcriptase or hepadnaviral reverse transcriptase includes the step of administering a pharmaceutically effective amount of a mappicine analog or a pharmaceutically acceptable salt thereof. A method of treating a patient infected with a retrovirus or hepadnavirus includes the step of administering a pharmaceutically effective amount of a mappicine analog or a pharmaceutically acceptable salt thereof