Ameya R Kirtane

US Patent:

20190125667, May 2, 2019

Filed:

Jun 21, 2018

Appl. No.:

16/014549

Inventors:

- Cambridge MA, US
- Boston MA, US
Carlo Giovanni Traverso - Newton MA, US
Robert S. Langer - Newton MA, US
Stacy Mo - Darien IL, US
Tyler Grant - Brighton MA, US
Mousa Jafari - Waltham MA, US
Dean Liang Glettig - Cambridge MA, US
Angela DiCiccio - San Francisco CA, US
Omar Abouzid - Cambridge MA, US
Ameya R. Kirtane - Quincy MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 9/00
A61K 47/32
A61K 31/7048
A61K 47/34
A61K 47/10
A61K 31/65

Abstract:

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

US Patent:

20190022227, Jan 24, 2019

Filed:

May 1, 2018

Appl. No.:

15/967844

Inventors:

- Minneapolis MN, US
Ameya Kirtane - Minneapolis MN, US
Ashley Haase - Minneapolis MN, US

International Classification:

A61K 47/10
A61K 9/00
A61K 31/717
A61P 31/00

Abstract:

Certain embodiments of the invention provide a pharmaceutical composition suitable for topical administration that comprises more than about 5% (w/w) glycerol monolaurate (GML), as well as methods of preparing and using such compositions.

US Patent:

20180243423, Aug 30, 2018

Filed:

Dec 13, 2017

Appl. No.:

15/841145

Inventors:

- Minneapolis MN, US
Tanmoy Sadhukha - Minneapolis MN, US
Ameya Kirtane - Minneapolis MN, US

Assignee:

REGENTS OF THE UNIVERSITY OF MINNESOTA - Minneapolis MN

International Classification:

A61K 47/42
A61K 47/69
A61K 49/00
A61K 47/62

Abstract:

Certain embodiments of the present invention provide functionalized nanoparticles and methods of use thereof. Certain embodiments provide nanoparticles functionalized with streptokinase. Certain embodiments of the present invention provide methods for treating a pathological fibrin associated disorder (e.g., cancer) in an animal.

US Patent:

20170266112, Sep 21, 2017

Filed:

Dec 16, 2016

Appl. No.:

15/382255

Inventors:

- Cambridge MA, US
- Boston MA, US
Carlo Giovanni Traverso - Newton MA, US
Robert S. Langer - Newton MA, US
Stacy Mo - Darien IL, US
Tyler Grant - Cambridge MA, US
Mousa Jafari - Boston MA, US
Dean Liang Glettig - Cambridge MA, US
Angela DiCiccio - Santa Clara CA, US
Omar Abouzid - Cambridge MA, US
Ameya R. Kirtane - Quincy MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 9/00
A61K 31/7048
A61K 31/65
A61K 47/34
A61K 47/10

Abstract:

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.