Amelia M Bartholomew

US Patent:

20130017175, Jan 17, 2013

Filed:

May 30, 2012

Appl. No.:

13/483910

Inventors:

Amelia Bartholomew - Lake Forest IL, US
Simon Lee - Chicago IL, US
Erzsebet Szilagyi - Chicago IL, US

Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - Urbana IL

International Classification:

A61K 35/28
A61P 17/02
A61P 29/00
C12N 5/0775
A61K 35/12

US Classification:

424 937, 435375, 435325, 435372

Abstract:

Inflammatory cytokines e.g. IFN-γ, serve as initiating stimuli for mesenchymal stem cell (MSC) immunosuppresive activity in vivo. Other inflammatory cytokines, such as TNF alpha, the molecule hemoxygenase I, and TLR ligation of MSC, may also provide such a response. Activated MSC's promote tissue regeneration in conditions such as aging, where regeneration is impaired. Wound healing in aged mammals was enhanced by restoring tensile strength to the levels of younger mammals. Activated MSCs were useful in treating wounds in diabetic primates.

US Patent:

20110178016, Jul 21, 2011

Filed:

Sep 30, 2009

Appl. No.:

13/121981

Inventors:

Amelia Bartholomew - Chicago IL, US
Eduardo Reina - Chicago IL, US
Alex Lyubimov - Chicago IL, US
Dan Cramer - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana

International Classification:

A61K 38/29
C07K 14/635
A61P 43/00
A61P 7/00
A61P 37/04

US Classification:

514 118, 530399

Abstract:

Currently there is no treatment for hematopoietic syndrome following radiation exposure. Exposed persons are presently treated with blood transfusions, growth factors such as G-CSF to promote neutrophil recovery. Present methods are targeted towards the bone marrow microenvironment, aiding in repair and regeneration with a decrease in the severity or possibly, complete avoidance of morbidity and mortality associated with the hematopoietic syndrome. Methods are useful for treatment of mass casualties following a radiation disaster.