Amedeo A Failli

US Patent:

6340687, Jan 22, 2002

Filed:

Sep 2, 1998

Appl. No.:

09/145895

Inventors:

Amedeo A. Failli - Princeton Junction NJ
Jay S. Shumsky - Hightstown NJ
Kevin A. Memoli - Cranbury NJ
Donald P. Strike - St. Davids PA

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C07D23940

US Classification:

514274, 544315

Abstract:

Antiatherosclerotic agents are provided having the following structure: wherein: R is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, or phenylalkyl of 7-10 carbon atoms; and R , R , R , R , and R are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 2-7 carbon atoms, alkynyl of 2-7 carbon atoms, aralkyl of 7-10 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy of 6-12 carbon atoms, aralkyloxy of 7-12 carbon atoms, fluoroalkoxy of 1-6 carbon atoms, trifluoromethyl, alkylthio of 1-3 carbon atoms, alkylsulfonyl of 1-3 carbon atoms, âSCF , nitro, alkylamino in which the alkylamino moiety has 1-6 carbon atoms, or dialkylamino in which each alkyl group has 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.

US Patent:

6344451, Feb 5, 2002

Filed:

Feb 1, 2000

Appl. No.:

09/495506

Inventors:

Robert J. Steffan - Langhorne PA
Amedeo A. Failli - Princeton Junction NJ

Assignee:

American Home Products - Madison NJ

International Classification:

A61K 3155

US Classification:

514220, 540561

Abstract:

The present invention provides compounds of the formula: wherein: X, Y and Z are independently selected from O, S, CH, CH , N, or NR ; W is moiety selected from (CH ) ; n=1-2; R , R are independently, hydrogen, straight chain alkyl (C -C ), branched chain alkyl (C -C ), cycloalkyl (C -C ), alkoxyalkyl (C -C ), halogen, straight or branched chain alkoxy (C -C ), hydroxy, CF , or perfluoroalkyl (C -C ); R is hydrogen or a straight chain alkyl group (C -C ), branched chain alkyl (C -C ), cycloalkyl (C -C ), alkoxyalkyl (C -C ), or hydroxyalkyl (C -C ); R is selected from hydrogen, or (lower alkyl (C -C ); and R is selected from halogen or hydrogen; or a pharmaceutically acceptable salt thereof: as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.

US Patent:

6455566, Sep 24, 2002

Filed:

Sep 2, 1998

Appl. No.:

09/145909

Inventors:

Robert J. Steffan - Langhorne PA
Amedeo A. Failli - Princeton Junction NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31415

US Classification:

514407, 5483717

Abstract:

Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is âwherein R , R , R , R , R , and R are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; R , and R are each, independently, hydrogen, lower alkyl of 1-6 carbon atoms, or CH COOR , where R is a lower alkyl of 1-6 carbon atoms; and X is O or S; R is hydrogen or a lower alkyl of 1-6 carbon atoms; R , R , and R are each, independently, hydrogen or halogen; and R is a lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.

US Patent:

6511974, Jan 28, 2003

Filed:

Jul 24, 1998

Appl. No.:

09/122020

Inventors:

John P. Dusza - Nanuet NY
Peter S. Chan - Monmouth Junction NJ
Jay D. Albright - Nanuet NY
Jehan F. Bagli - Princeton NJ
Amedeo A. Failli - Princeton NJ
Mark A. Ashwell - Plainsboro NJ
Albert J. Molinari - Princeton NJ
Thomas J. Caggiano - Morrisville PA
Eugene J. Trybulski - Princeton Junction NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3155

US Classification:

514220, 514 63, 540558, 540561, 540562, 540565

Abstract:

This invention relates to new compounds selected from those of the general formula (I), or a pharmaceutically acceptable salt, ester or prodrug form thereof: wherein D, E and G are N or CH, which serve as vasopressin agonists and are useful in treating disorders such as diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, and the inability to temporarily delay urination and pharmaceutical compositions and methods for same.

US Patent:

6620807, Sep 16, 2003

Filed:

Feb 1, 2000

Appl. No.:

09/495507

Inventors:

Robert J. Steffan - Langhorne PA
Amedeo A. Failli - Princeton Junction NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3155

US Classification:

514220, 5142111, 540548, 540557

Abstract:

The present invention provides benzoheterocyclic carboxyamides, particularly pyridobenzodiazepine and pyridobenzoxazepine carboxyamides, of the general formula: wherein: W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilizing these compounds for providing a temporary delay of urination or for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding or coagulation disorders.

US Patent:

6686476, Feb 3, 2004

Filed:

Aug 6, 2002

Appl. No.:

10/212888

Inventors:

Robert J. Steffan - Langhorne PA
Amedeo A. Failli - Princeton Junction NJ

Assignee:

Wyeth - Madison NJ

International Classification:

C07D27728

US Classification:

548196, 548233

Abstract:

Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is wherein R , R , R , R , R , and R are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; R , and R are each, independently, hydrogen, lower alkyl of 1-6 carbon atoms, or CH COOR , where R is a lower alkyl of 1-6 carbon atoms; and X is O or S; R is hydrogen or a lower alkyl of 1-6 carbon atoms; R , R , and R are each, independently, hydrogen or halogen; and R is a lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.

US Patent:

6713607, Mar 30, 2004

Filed:

Sep 13, 2001

Appl. No.:

09/950634

Inventors:

Thomas J. Caggiano - Morrisville PA
Yanqiu Chen - New York NY
Amedeo A. Failli - Princeton NJ
Koji Nakanishi - New York NY

Assignee:

Wyeth - Madison NJ

International Classification:

C07K 100

US Classification:

530350

Abstract:

This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.

US Patent:

6894061, May 17, 2005

Filed:

Nov 20, 2003

Appl. No.:

10/718461

Inventors:

Albert John Molinari - Pottstown PA, US
Mark Antony Ashwell - Carlisle MA, US
Brian Hugh Ridgway - Belmont CA, US
Amedeo Arturo Failli - Princeton Junction NJ, US
William Jay Moore - Collegeville PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K031/473
C07D221/12

US Classification:

514298, 546108, 546109, 546110, 544324, 514269

Abstract:

This invention provides a compound of formulae (I) or (II) having the structure or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.