Amber M Lee

US Patent:

20220273724, Sep 1, 2022

Filed:

Feb 17, 2022

Appl. No.:

17/674770

Inventors:

- Rockville MD, US
Braden Carl ISHLER - Gaithersburg MD, US
William Matthew DICKERSON - Washington DC, US
Narendra Nath TANDON - Gaithersburg MD, US
Amber Nicole LEE - Rockville MD, US
Stephon Edward AMOS - Buckeystown MD, US
Rafael JORDA - Merignac, FR
Michael Alexander MATHEWS - Arlington VA, US

Assignee:

CELLPHIRE INC. - Rockville MD

International Classification:

A61K 35/19
A61P 7/04
A61K 9/19

Abstract:

Provided herein are methods and compositions for treating a coagulopathy in a subject. Such methods can include administering to the subject in need thereof, for example because they have been administered an anticoagulant agent, an effective amount of a composition including platelets, or in illustrative embodiments platelet derivatives, and in further illustrative embodiments freeze-dried platelet derivatives (FDPDs). Various properties of exemplary embodiments of such methods and platelet derivatives used therein, as well as numerous additional aspects and embodiments are provided herein.

US Patent:

20210315935, Oct 14, 2021

Filed:

Feb 3, 2021

Appl. No.:

17/166490

Inventors:

- Rockville MD, US
Shan Xu - Rockville MD, US
William Matthew Dickerson - Washington DC, US
Amber Nicole Lee - Rockville MD, US
Braden Carl Ishler - Gaithersburg MD, US
Daniel Allen Sheik - Rockville MD, US

International Classification:

A61K 35/19
A61K 9/19

Abstract:

Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

US Patent:

20210308066, Oct 7, 2021

Filed:

Feb 3, 2021

Appl. No.:

17/166487

Inventors:

- Rockville MD, US
Shan Xu - Rockville MD, US
William Matthew Dickerson - Washington DC, US
Amber Nicole Lee - Rockville MD, US
Braden Carl Ishler - Gaithersburg MD, US
Daniel Allen Sheik - Rockville MD, US

International Classification:

A61K 9/50
C12N 5/078
A61P 7/04
A61K 35/19
A61K 31/197

Abstract:

Provided herein are methods for preparing anti-fibrinolytic loaded platelets, platelet derivatives, thrombosomes and compositions thereof.

US Patent:

20210308185, Oct 7, 2021

Filed:

Feb 3, 2021

Appl. No.:

17/166648

Inventors:

- Rockville MD, US
Shan Xu - Rockville MD, US
William Matthew Dickerson - Washington DC, US
Amber Nicole Lee - Rockville MD, US
Braden Carl Ishler - Gaithersburg MD, US
Daniel Allen Sheik - Rockville MD, US
Narendra Nath Tandon - Gaithersburg MD, US

International Classification:

A61K 35/19
A61K 31/197
A61P 7/04

Abstract:

Provided herein are methods and compositions for treating acquired hemophilia with platelets and/or platelet derivatives. In some cases, the platelets and or platelet derivatives are loaded with an anti-fibrinolytic.

US Patent:

20210299179, Sep 30, 2021

Filed:

Feb 3, 2021

Appl. No.:

17/166605

Inventors:

- Rockville MD, US
Shan Xu - Rockville MD, US
William Matthew Dickerson - Washington DC, US
Amber Nicole Lee - Rockville MD, US
Braden Carl Ishler - Gaithersburg MD, US
Daniel Allen Sheik - Rockville MD, US
Narendra Nath Tandon - Gaithersburg MD, US

International Classification:

A61K 35/19
A61K 31/197
A61K 38/57
A61K 31/195
A61K 38/36
A61P 7/04

Abstract:

Provided herein are methods and compositions for treating congenital hemophilia with platelets and/or platelet derivatives. In some cases, the platelets and or platelet derivatives are loaded with an anti-fibrinolytic.

US Patent:

20210046120, Feb 18, 2021

Filed:

Aug 14, 2020

Appl. No.:

16/994330

Inventors:

- Rockville MD, US
Braden Carl Ishler - Gaithersburg SD, US
William Matthew Dickerson - Washington DC, US
Amber Nicole Lee - Rockville MD, US
Shan Xu - Rockville MD, US

International Classification:

A61K 35/19
A61K 31/352
A61P 7/04
A61K 31/7008
A61K 47/42
A61K 47/26

Abstract:

In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent.

US Patent:

20210046121, Feb 18, 2021

Filed:

Aug 14, 2020

Appl. No.:

16/994377

Inventors:

- Rockville MD, US
Braden Carl Ishler - Gaithersburg SD, US
William Matthew Dickerson - Washington DC, US
Narendra Nath Tandon - Gaithersburg MD, US
Amber Nicole Lee - Rockville MD, US

International Classification:

A61K 35/19
A61P 7/04
A61K 47/42
A61K 47/26
A61K 45/06

Abstract:

In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.

US Patent:

20200346167, Nov 5, 2020

Filed:

May 1, 2020

Appl. No.:

16/865215

Inventors:

- Rockville MD, US
Braden Carl Ishler - Gaithersburg MD, US
Stephen Edward Amos - Buckeystown MD, US
Keith Andrew Moskowitz - Westfield IN, US
Amber Nicole Lee - Rockville MD, US
Rafael Jorda - Bethesda MD, US
Glen Michael Fitzpatrick - North Potomac MD, US
Michael Alexander Mathews - Arlington VA, US

International Classification:

B01D 61/14
C12N 5/078

Abstract:

Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.