Alyssa M Boasso

US Patent:

20230022546, Jan 26, 2023

Filed:

Mar 8, 2022

Appl. No.:

17/300314

Inventors:

- Cambridge MA, US
Evan Hempel - Cambridge MA, US
Colleen Cotter - Cambridge MA, US
Aylin Cimenser - Cambridge MA, US
Alyssa Boasso - Cambridge MA, US
Holly Mrozak - Cambridge MA, US
Alex Konisky - Cambridge MA, US
Nathan Strozewski - Cambridge MA, US
Taylor Travers - Cambridge MA, US
Martin Williams - Cambridge MA, US
Kim Kwan - Cambridge MA, US
Brent Vaughan - Cambridge MA, US
Tom Megerian - Cambridge MA, US

International Classification:

A61N 1/36

Abstract:

Systems and methods of the present disclosure are directed to neural stimulation via non-invasive sensory stimuli. The non-invasive sensory stimuli can reduce neuroinflammation, improving synaptic plasticity and stimulating neural networking, and improving microglial-mediated clearance of cerebral insults, which would otherwise contribute to the progression of brain atrophy, by inducing synchronized gamma oscillations in at least one region of a brain in a subject. Stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stem from progression of brain atrophy.

US Patent:

20210060330, Mar 4, 2021

Filed:

Sep 29, 2020

Appl. No.:

17/035689

Inventors:

- Brooklyn NY, US
Miles Thibault - Boston MA, US
Kelsey Fafara - Watertown MA, US
Francois Kress - New York NY, US
Rohan Ajay Verma - Cambridge MA, US
Alyssa Boasso - Brookline MA, US
Sean Hagberg - Cranston RI, US
Julia Brock - Yarmouth ME, US

International Classification:

A61N 1/04
A61N 1/375
A61N 1/36
A61H 23/02
A61H 23/00

Abstract:

Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.

US Patent:

20200155790, May 21, 2020

Filed:

Jan 5, 2016

Appl. No.:

15/536151

Inventors:

- Los Gatos CA, US
Alyssa M. BOASSO - Brookline MA, US
Hailey M. MORTIMORE - Boston MA, US
Rhonda S. SILVA - Boston MA, US
Sumon K. PAL - Boston MA, US
Jonathan CHARLESWORTH - Boston MA, US

International Classification:

A61M 21/02
A61N 1/04
A61N 1/36
A61M 21/00
A61M 16/06

Abstract:

Methods and apparatuses for improving sleep by transdermal electrical stimulation (TES). In general, described herein are methods for applying TES to a subject, and particularly the subject's head (e.g., temple/forehead region) and/or neck with an TES waveform adapted to improve sleep, including reducing sleep onset (falling to sleep) more quickly and/or lengthening the duration of sleep. TES waveform(s) particularly well suited to enhancing sleep are also described herein.

US Patent:

20200054873, Feb 20, 2020

Filed:

Oct 18, 2019

Appl. No.:

16/657073

Inventors:

- Cambridge MA, US
Miles Thibault - Boston MA, US
Kelsey Fafara - Watertown MA, US
Francois Kress - New York NY, US
Rohan Ajay Verma - Cambridge MA, US
Alyssa Boasso - Brookline MA, US
Sean Hagberg - Cranston RI, US
Julia Brock - Yarmouth ME, US

International Classification:

A61N 1/04
A61N 1/36
A61N 1/375
A61H 23/00
A61H 23/02

Abstract:

Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.

US Patent:

20190336765, Nov 7, 2019

Filed:

May 20, 2019

Appl. No.:

16/417625

Inventors:

- Los Gatos CA, US
Sumon K. PAL - Boston MA, US
William J. TYLER - Newton MA, US
Daniel Z. WETMORE - Brooklyn NY, US
Isy GOLDWASSER - Los Gatos CA, US
Alyssa M. BOASSO - Brookline MA, US
Hailey M. MORTIMORE - Boston MA, US
Rafal PIERSIAK - Los Gatos CA, US

International Classification:

A61N 1/36

Abstract:

Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state by applying stimulation to the subject's skin. One or more electrode may be on the subject's mastoid, and/or on or near the back of the subject's neck. The portable applicators are configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect to stimulate either the trigeminal, facial and/or cervical plexus. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator.

US Patent:

20190232046, Aug 1, 2019

Filed:

Jan 7, 2019

Appl. No.:

16/241224

Inventors:

- Cambridge MA, US
Miles Thibault - Boston MA, US
Kelsey Fafara - Watertown MA, US
Francois Kress - New York NY, US
Rohan Ajay Verma - Boston MA, US
Alyssa Boasso - Brookline MA, US
Sean Hagberg - Cranston RI, US

International Classification:

A61N 1/04
A61N 1/36
A61N 1/375

Abstract:

Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.

US Patent:

20190232047, Aug 1, 2019

Filed:

Jan 7, 2019

Appl. No.:

16/241227

Inventors:

- Cambridge MA, US
Miles Thibault - Boston MA, US
Kelsey Fafara - Watertown MA, US
Francois Kress - New York NY, US
Rohan Ajay Verma - Boston MA, US
Alyssa Boasso - Brookline MA, US
Sean Hagberg - Cranston RI, US

International Classification:

A61N 1/04
A61N 1/36
A61N 1/375

Abstract:

Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject. As described herein, in certain embodiments, the delivery of mechanical stimulation to a subject provides for treatment of anxiety.

US Patent:

20170197081, Jul 13, 2017

Filed:

Dec 19, 2016

Appl. No.:

15/384249

Inventors:

Jonathan D. CHARLESWORTH - Menlo Park CA, US
Sumon K. PAL - Boston MA, US
William J. TYLER - Newton MA, US
Daniel Z. WETMORE - Brooklyn NY, US
Isy GOLDWASSER - Los Gatos CA, US
Alyssa M. BOASSO - Brookline MA, US
Hailey M. MORTIMORE - Boston MA, US
Rhonda S. SILVA - Boston MA, US
Rafal PIERSIAK - Los Gatos CA, US

International Classification:

A61N 1/36

Abstract:

Portable transdermal electrical stimulation (TES) applicators for modifying a subject's cognitive state by applying stimulation to the subject's skin. One or more electrode may be on the subject's mastoid, and/or on or near the back of the subject's neck. The portable applicators are configured and adapted to be lightweight and may be wearable, and to deliver a high-intensity TES able to evoke or enhance a predetermined cognitive effect to stimulate either the trigeminal, facial and/or cervical plexus. These TES applicators may include a pair of electrodes and a TES control module comprising a processor, a timer and a waveform generator.