Zhaoqing Wang - Greenwood IN William Delaney - Bear DE Ashok Tehim - Ridgewood NJ Shawn Maddaford - Mississauga, CA Ian Egle - Mississauga, CA Richard Schumacher - Monroe NY Allen T. Hopper - Glen Rock NJ
Assignee:
NPS Allelix Corp. - Mississauga Allelix Neuroscience, Inc. - Salt Lake City UT
International Classification:
A61K 3138
US Classification:
514444, 514438, 549 77, 549 59
Abstract:
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
Richard A. Schumacher - Monroe NY William F. Brubaker - Cheshire CT Michael De Vivo - New York NY Allen Hopper - Glen Rock NJ Ashok Tehim - Ridgewood NJ Ruiping Liu - Huntington NY Axel Unterbeck - Madison CT
PDE4 inhibition is achieved by novel compounds, e. g. , N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R , R , R and R are as defined herein.
PDE4 inhibition is achieved by novel nitroxide compounds, e. g. , N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I–III:.
Phosphodiesterase 4 Inhibitors, Including Aminoindazole And Aminobenzofuran Analogs
PDE4 inhibition is achieved by novel compounds, e. g. , aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II:.
Richard A. Schumacher - Monroe NY, US William F. Brubaker - Cheshire CT, US Michael De Vivo - New York NY, US Hans-Jürgen Ernst Hess - Old Lyme CT, US Allen Hopper - Glen Rock NJ, US Ashok Tehim - Ridgewood NJ, US Ruiping Liu - Huntington NY, US Axel Unterbeck - Madison CT, US
PDE4 inhibition is achieved by novel compounds, e. g. , N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I:.
Allen Hopper - Glen Rock NJ, US Erik Kuester - Franklin NJ, US Robert Dunn - Towaco NJ, US Richard Conticello - Ossining NY, US
Assignee:
Memory Pharmaceutical Corporation - Montvale NJ
International Classification:
A61K 31/437 A61K 31/4155 C07D 231/54 C07D 471/06
US Classification:
514303, 514406, 546119, 5483611
Abstract:
Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
Ruiping Liu - Huntington NY, US Mike De Vivo - New York NY, US Hans-Jurgen Ernst Hess - Old Lyme CT, US Allen Hopper - Glen Rock NJ, US Erik Kuester - Franklin NJ, US Ashok Tehim - Ridgewood NJ, US
Assignee:
Memory Pharmaceuticals Corp. - Montvale NJ
International Classification:
A61K 31/40 C09D 409/00
US Classification:
514422, 548518, 548527
Abstract:
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein.
Heterocyclic Compounds, Methods For The Preparation Thereof, And Uses Thereof
Brian Herbert - Stockholm NJ, US Wenge Xie - Mahwah NY, US Truc Minh Nguyen - New York NY, US Allen T Hopper - Glen Rock NJ, US Ashok Tehim - Ridgewood NJ, US
Assignee:
Memory Pharmaceuticals Corp. - Montvale NJ
International Classification:
C07D 401/02 A61K 31/44
US Classification:
514333, 514334, 546256, 546257
Abstract:
The compounds of the present invention are of formula I: wherein A, R, Ris as defined herein, are useful as ligands for nicotinic receptors.