Allan Clyde Darling

US Patent:

20220280550, Sep 8, 2022

Filed:

May 16, 2022

Appl. No.:

17/745464

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20220280551, Sep 8, 2022

Filed:

May 16, 2022

Appl. No.:

17/745487

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20220280552, Sep 8, 2022

Filed:

May 16, 2022

Appl. No.:

17/745491

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20220280553, Sep 8, 2022

Filed:

May 16, 2022

Appl. No.:

17/745497

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20220280554, Sep 8, 2022

Filed:

May 16, 2022

Appl. No.:

17/745505

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20220273697, Sep 1, 2022

Filed:

May 16, 2022

Appl. No.:

17/745470

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20230095371, Mar 30, 2023

Filed:

Nov 30, 2022

Appl. No.:

18/072260

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

US Patent:

20230068856, Mar 2, 2023

Filed:

Oct 20, 2022

Appl. No.:

17/970080

Inventors:

- West Hollywood CA, US
Allan Darling - North Potomac MD, US

International Classification:

A61K 31/724
A61K 9/00
A61K 9/08

Abstract:

This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.