Alice C Mchardy from Ridgefield, CT, age 47

Ribonucleic Acid Interference Molecules And Binding Sites Derived By Analyzing Intergenic And Intronic Regions Of Genomes
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US Patent:

8178503, May 15, 2012
Filed:

Apr 21, 2006
Appl. No.:

11/408557
Inventors:

Isidore Rigoutsos - Astoria NY, US
Tien Huynh - Yorktown Heights NY, US
Aristotelis Tsirigos - Astoria NY, US
Alice Carolyn McHardy - New York NY, US
Assignee:

International Business Machines Corporation - Armonk NY
International Classification:

C12N 15/11
US Classification:

514 44A
Abstract:

In one aspect of the invention, a method for regulating the expression of a transcript comprises using at least one interfering RNA molecule that binds to an area of transcript containing a region that corresponds to at least one sequence having SEQ ID NO: 1, the interfering RNA molecule regulating the expression of the transcript through post-transcriptional silencing. In another aspect, a method for regulating the expression of a transcript comprises at least one of the provided sequences having SEQ ID NO: 1 being used to design an interfering RNA molecule that contains a region that corresponds to the reverse complement of one or more sequences having SEQ ID NO: 1, the interfering molecule regulating, through post-transcriptional silencing, transcripts that contain the sequence having SEQ ID NO: 1.

Techniques For Linking Non-Coding And Gene-Coding Deoxyribonucleic Acid Sequences And Applications Thereof
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US Patent:

20070042397, Feb 22, 2007
Filed:

Mar 3, 2006
Appl. No.:

11/367512
Inventors:

Isidore Rigoutsos - Astoria NY, US
Tien Huynh - Yorktown Heights NY, US
Aristotelis Tsirigos - Astoria NY, US
Alice McHardy - New York NY, US
Kevin Miranda - McDowall, AU
Assignee:

International Business Machines Corporation - Armonk NY
International Classification:

C12Q 1/68
G06F 19/00
US Classification:

435006000, 702020000
Abstract:

Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.

Techniques For Linking Non-Coding And Gene-Coding Deoxyribonucleic Acid Sequences And Applications Thereof
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US Patent:

20080052008, Feb 28, 2008
Filed:

Oct 30, 2007
Appl. No.:

11/928611
Inventors:

Isidore Rigoutsos - Astoria NY, US
Tien Huynh - Yorktown Heights NY, US
Aristotelis Tsirigos - Astoria NY, US
Alice McHardy - New York NY, US
Kevin Miranda - McDowall, AU
Assignee:

International Business Machines Corporation - Armonk NY
International Classification:

G06F 19/00
C07H 21/04
C12Q 1/68
US Classification:

702020000, 435006000, 536024100
Abstract:

Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.

Techniques For Linking Non-Coding And Gene-Coding Deoxyribonucleic Acid Sequences And Applications Thereof
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US Patent:

20090093624, Apr 9, 2009
Filed:

Oct 30, 2007
Appl. No.:

11/928523
Inventors:

Isidore Rigoutsos - Asloria NY, US
Tien Huynh - Yorktown Heights NY, US
Aristotelis Tsirigos - Astoria NY, US
Alice Carolyn McHardy - New York NY, US
Kevin Charles Miranda - McDowall, AU
Assignee:

International Business Machines Corporation - Armonk NY
International Classification:

C07H 21/02
US Classification:

536 254
Abstract:

Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.

Alice C Mchardy