Alfredo P Grossi

US Patent:

20100048489, Feb 25, 2010

Filed:

Aug 14, 2009

Appl. No.:

12/541410

Inventors:

Angelika Fretzen - Somerville MA, US
Steven Witowski - Melrose MA, US
Alfredo Grossi - Somerville MA, US
Hong Zhao - Lexington MA, US
Mahendra Dedhiya - Pomona NY, US
Yun Mo - Commack NY, US

Assignee:

Ironwood Pharmaceuticals Inc. - Cambridge MA

International Classification:

A61K 38/10
A61P 1/00

US Classification:

514 14

Abstract:

Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

US Patent:

20100074949, Mar 25, 2010

Filed:

Aug 13, 2009

Appl. No.:

12/583066

Inventors:

William Rowe - Medford MA, US
Patricia Hurter - Harvard MA, US
Christopher Young - Waltham MA, US
Kirk Dinehart - Holliston MA, US
Marinus Jacobus Verwijs - Framingham MA, US
Kirk Overhoff - Waltham MA, US
Peter D.J. Grootenhuis - San Diego CA, US
Martyn Botfield - Concord MA, US
Alfredo Grossi - Somerville MA, US

International Classification:

A61K 9/28
A61K 31/47
A61K 9/42
A61K 9/44
A61P 3/00
A61P 19/10

US Classification:

424467, 514312, 424474, 424476

Abstract:

The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

US Patent:

20100256184, Oct 7, 2010

Filed:

Feb 18, 2010

Appl. No.:

12/708359

Inventors:

William Rowe - Medford MA, US
Patricia Hurter - Harvard MA, US
Christopher R. Young - Waltham MA, US
Kirk Dinehart - Holliston MA, US
Marinus Jacobus Verwijs - Framingham MA, US
Kirk Overhoff - Waltham MA, US
Peter D.J. Grootenhuis - San Diego CA, US
Martyn Botfield - Concord MA, US
Alfredo Grossi - Somerville MA, US
Gregor Zlokarnik - La Jolla CA, US
Fredrick F. Van Goor - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/47
A61P 19/10
A61P 19/08
A61P 11/00

US Classification:

514312

Abstract:

The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

US Patent:

20110059903, Mar 10, 2011

Filed:

Aug 5, 2010

Appl. No.:

12/851330

Inventors:

Angelika Fretzen - Somerville MA, US
Steven Witowski - Melrose MA, US
Alfredo Grossi - Somerville MA, US
Hong Zhao - Somerville MA, US
Mahendra Dedhiya - Pomona NY, US
Yun Mo - Commack NY, US

Assignee:

Ironwood Pharmaceuticals, Inc. - Cambridge MA
Forest Laboratories Holdings Limited - Hamilton

International Classification:

A61K 38/12
A61P 1/00

US Classification:

514 211

Abstract:

The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.

US Patent:

20120009225, Jan 12, 2012

Filed:

Aug 14, 2009

Appl. No.:

13/062332

Inventors:

Angelika Fretzen - Somerville MA, US
Steven Witowski - Melrose MA, US
Alfredo Grossi - Somerville MA, US
Hong Zhao - Somerville MA, US

Assignee:

Ironwood Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 9/14
A61K 9/00
A61K 9/48
A61K 38/02

US Classification:

424400, 514 11, 427 214

Abstract:

Solid, stable formulations of therapeutic polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The therapeutic polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

US Patent:

20120039949, Feb 16, 2012

Filed:

Aug 14, 2009

Appl. No.:

13/062324

Inventors:

Angelika Fretzen - Somerville MA, US
Steven Witowski - Melrose MA, US
Alfredo Grossi - Somerville MA, US
Hong Zhao - Somerville MA, US

Assignee:

Ironwood Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 9/00
A61P 29/00
A61P 1/00
A61K 38/02
A61K 38/10

US Classification:

424400, 514 11, 514 215, 514 214

Abstract:

Solid, stable formulations of GC-C receptor agonist polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The GC-C receptor agonist polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

US Patent:

20120213846, Aug 23, 2012

Filed:

Aug 14, 2009

Appl. No.:

13/059154

Inventors:

Angelika Fretzen - Somerville MA, US
Steven Witowski - Melrose MA, US
Alfredo Grossi - Somerville MA, US
Hong Zhao - Lexington MA, US
Mahendra Dedhiya - Pomona NY, US
Yun Mo - Commack NY, US

Assignee:

Forest Laboratories Holdings Limited - Hamilton
Ironwood Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 38/12
A61K 9/48
A61P 1/10
A61P 1/04
A61P 1/00
B05D 5/00
A61K 9/20

US Classification:

424451, 514 211, 427 214, 424464

Abstract:

Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

US Patent:

20120220625, Aug 30, 2012

Filed:

Feb 10, 2012

Appl. No.:

13/370540

Inventors:

William Rowe - Medford MA, US
Patricia Hurter - Harvard MA, US
Christopher R. Young - Waltham MA, US
Kirk Dinehart - Holliston MA, US
Marinus Jacobus Verwijs - Framingham MA, US
Kirk Overhoff - Waltham MA, US
Peter D.J. Grootenhuis - San Diego CA, US
Martyn Botfield - Concord MA, US
Alfredo Grossi - Somerville MA, US
Gregor Zlokarnik - La Jolla CA, US
Fredrick F. Van Goor - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/47
A61P 19/08
A61P 11/00
A61P 19/10

US Classification:

514312

Abstract:

The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.