Alfred A Reszka from New Hope, PA, age 61

Compositions And Methods For Inhibiting Bone Resorption
view source
US Patent:

6432931, Aug 13, 2002
Filed:

Jun 21, 1999
Appl. No.:

09/336950
Inventors:

Alfred A. Reszka - Glenside PA
Edward S. Scolnick - Wynnwood PA
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 3166
US Classification:

514108, 514762
Abstract:

The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of an isoprenoid compound.

Compositions And Methods For Inhibiting Bone Resorption
view source
US Patent:

6699850, Mar 2, 2004
Filed:

Dec 21, 2001
Appl. No.:

10/029678
Inventors:

Alfred A. Reszka - Glenside PA
Edward S. Scolnick - Wynnewood PA
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 3166
US Classification:

514107, 514108, 514109
Abstract:

The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of an isoprenoid compound.

Antibodies Specific For Dkk-1
view source
US Patent:

7994293, Aug 9, 2011
Filed:

Feb 6, 2008
Appl. No.:

12/012885
Inventors:

Zhiqiang An - Ambler PA, US
Fang Chen - North Wales PA, US
John E. Fisher - Jenkintown PA, US
Helmut Glantschnig - Schwenksville PA, US
Donald B. Kimmel - Doylestown PA, US
Alfred A. Reszka - New Hope PA, US
Fubao Wang - Dresher PA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

C07K 16/24
C07K 16/00
US Classification:

53038823, 5303871, 5303879, 5303881
Abstract:

Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.

Methods Of Identifying Modulators Of Kinases Responsive To Stress
view source
US Patent:

20010014329, Aug 16, 2001
Filed:

Jan 27, 1999
Appl. No.:

09/238536
Inventors:

ALFRED A. RESZKA - GLENSIDE PA, US
GIDEON A. RODAN - BRYN MAWR PA, US
International Classification:

A61K039/395
US Classification:

424/146100, 424/141100
Abstract:

The present invention relates to methods of identifying compounds useful as modulators of certain stress responsive kinases. More particularly, the compounds so identified are useful for treating or preventing diseases or conditions that are mediated by, for example, abnormal bone resorption or angiogenesis. These compounds are useful for treating or preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, and tumor growth.

Methods For Identifying Compounds Useful For Inhibiting Geranylgeranyl Diphosphate Synthase
view source
US Patent:

20020004218, Jan 10, 2002
Filed:

Mar 26, 2001
Appl. No.:

09/817432
Inventors:

Gideon Rodan - Bryn Mawr PA, US
Alfred Reszka - Glenside PA, US
International Classification:

C12Q001/42
US Classification:

435/021000
Abstract:

The present invention relates to methods for identifying compounds useful as inhibitors of geranylgeranyl diphosphate synthase. More particularly, the compounds so identified are useful for inhibiting bone resorption. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a geranylgeranyl diphosphate synthase inhibitor.

Methods For Identifying Compounds Useful For Inhibiting Farnesyl Diphosphate Synthase
view source
US Patent:

20020151459, Oct 17, 2002
Filed:

Apr 11, 2002
Appl. No.:

10/121465
Inventors:

James Bergstrom - Neshanic Station NJ, US
Alfred Reszka - Glenside PA, US
Gideon Rodan - Bryn Mawr PA, US
Assignee:

Merck & Co., Inc.
International Classification:

A61K031/00
C12Q001/48
US Classification:

514/001000, 435/015000
Abstract:

The present invention relates to methods for identifying compounds useful as inhibitors of farnesyl diphosphate synthase. More particularly, the compounds so identified are useful for inhibiting bone resorption. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a farnesyl diphosphate synthase inhibitor.

Compositions And Methods For Inhibiting Bone Resorption
view source
US Patent:

20030078211, Apr 24, 2003
Filed:

Mar 25, 2002
Appl. No.:

10/105779
Inventors:

Alfred Reszka - Glenside PA, US
Assignee:

Merck & Co., Inc.
International Classification:

A61K038/04
C07K017/00
C07K016/00
C07K007/00
C07K005/00
A61K038/00
US Classification:

514/017000, 530/328000, 530/329000
Abstract:

The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a caspase inhibitor.

Compositions And Methods For Inhibiting Bone Resorption
view source
US Patent:

20040180862, Sep 16, 2004
Filed:

Dec 5, 2003
Appl. No.:

10/479922
Inventors:

Alfred Reszka - Glenside PA, US
John Fisher - Jenkintown PA, US
International Classification:

A61K031/675
A61K031/663
US Classification:

514/089000, 514/102000
Abstract:

The present invention relates to parenteral compositions and methods for inhibiting bone resorption in a mammal while counteracting potential local irritation at injection sites. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a farnesyl diphosphate synthase inhibiting bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a squalene synthase inhibitor.

Alfred A Reszka