Alfred W Lasher

US Patent:

20070269456, Nov 22, 2007

Filed:

Mar 6, 2007

Appl. No.:

11/714302

Inventors:

Alfred Lasher - Houston TX, US
Joseph Kittle - Irvine CA, US
Steven Widen - Galveston TX, US

International Classification:

A61K 39/00
A61P 31/04
A61P 31/12
A61P 31/16
A61P 31/18

US Classification:

424208100, 424209100, 424224100, 424233100, 424243100, 424244100, 424246100, 424257100, 424258100

Abstract:

The invention is a general method for improving the performance of the DNA-based vaccines. The method utilizes a complex DNA-generated profile of antigens to extend the effects of DNA-based vaccines and to broaden the immune response. This broadened immune response in turn improves the protection of the recipient from divergent (but related) strains of a pathogen. In addition, it effectively improves the efficacy of DNA-based vaccines used for treatment of viral diseases, including acquired immunity disorder (AIDS). One embodiment, where the target viral pathogen is HIV (the causative agent for aids), the method identifies an orderly set of plasmids of related sequences that may be used to prime a broad and strong immune response to HLA-restricted viral antigens. This mixture of plasmids is thus capable of priming an appropriate immune response to reduce the viral burden in HIV infected patients or to protect uninfected patients from HIV infection.

US Patent:

20060211080, Sep 21, 2006

Filed:

Mar 16, 2005

Appl. No.:

11/081277

Inventors:

James Frost - The Woodlands TX, US
Alfred Lasher - Houston TX, US
Steven Widen - Pearland TX, US

Assignee:

Picoscript Ltd., L.L.P. - Houston TX

International Classification:

C12Q 1/24
C12M 1/36

US Classification:

435030000, 435286300, 435286400

Abstract:

The present invention relates to a robotic apparatus and method for automating the spreading of a biologic sample on a plate, wherein the robot includes at least one effector arm to hold and shake the plate and a pipetting arm to deliver the sample to the plate. The present invention also includes the spreading of the biologic sample being assisted by at least one bead being rolled on the interior bottom surface of the plate and then removed from the plate.

US Patent:

20180117180, May 3, 2018

Filed:

Jun 27, 2017

Appl. No.:

15/635114

Inventors:

Alfred W. Lasher - Houston TX, US
Steven G. Widen - Galveston TX, US

International Classification:

A61K 48/00
A61K 39/21
A61K 39/12
A61K 39/00

Abstract:

The invention is a general method for improving the performance of the DNA-based vaccines. The method utilizes a complex DNA-generated profile of antigens to extend the effects of DNA-based vaccines and to broaden the immune response. This broadened immune response in turn improves the protection of the recipient from divergent (but related) strains of a pathogen. In addition, it effectively improves the efficacy of DNA-based vaccines used for treatment of viral diseases, including acquired immunity disorder (AIDS). One embodiment, where the target viral pathogen is HIV (the causative agent for aids), the method identifies an orderly set of plasmids of related sequences that may be used to prime a broad and strong immune response to HLA-restricted viral antigens. This mixture of plasmids is thus capable of priming an appropriate immune response to reduce the viral burden in HIV infected patients or to protect uninfected patients from HIV infection.