Alfred C Greenquist from 1990 Colusa Way, San Jose, CA 95130, age 80, Phone: 408 374-1389

Us Patents

Systems And Methods For Discovery And Analysis Of Markers
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US Patent:

7425700, Sep 16, 2008
Filed:

Jul 8, 2005
Appl. No.:

11/178262
Inventors:

John T. Stults - Redwood City CA, US
Alfred Greenquist - San Jose CA, US
Alexander Sassi - Berkeley CA, US
International Classification:

H01J 49/04
H01J 49/10
B01D 59/44
US Classification:

250288, 250282, 250281, 2101982, 210243
Abstract:

The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.

Systems And Method For Discovery And Analysis Of Markers
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US Patent:

7906758, Mar 15, 2011
Filed:

Jul 14, 2008
Appl. No.:

12/172988
Inventors:

John T. Stults - Redwood City CA, US
Alfred Greenquist - San Jose CA, US
Alexander Sassi - Berkeley CA, US
International Classification:

B01D 59/44
US Classification:

250282, 250281, 250288, 435 6, 435 71, 435 723, 436 52, 436 63, 436 64, 514 13, 514 14, 702 19, 702 22, 706 16, 706 48
Abstract:

The present invention relates to a charged particle beam apparatus which employs a scanning electron microscope for sample inspection and defect review. The present invent provides solution of improving imaging resolution by utilizing a field emission cathode tip with a large tip radius, applying a large accelerating voltage across ground potential between the cathode and anode, positioning the beam limit aperture before condenser lens, utilizing condenser lens excitation current to optimize image resolution, applying a high tube bias to shorten electron travel time, adopting and modifying SORIL objective lens to ameliorate aberration at large field of view and under electric drifting and reduce the urgency of water cooling objective lens while operating material analysis. The present invent provides solution of improving throughput by utilizing fast scanning ability of SORIL and providing a large voltage difference between sample and detectors.

Assay Customization
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US Patent:

20040235052, Nov 25, 2004
Filed:

Jan 16, 2004
Appl. No.:

10/760100
Inventors:

Jonathan Heller - San Francisco CA, US
Carol Dahl - Mercer Island WA, US
John Stults - Redwood City CA, US
Peter Foley - Los Altos Hills CA, US
Stoughton Ellsworth - Palo Alto CA, US
Frank Andel - Berkeley CA, US
Alfred Greenquist - San Jose CA, US
Assignee:

Biospect, Inc. - South San Francisco CA
International Classification:

G01N033/53
G06F019/00
G01N033/48
G01N033/50
US Classification:

435/007100, 702/019000
Abstract:

Systems for customization of assays. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the system performs optimized assays for greater sensitivity, specificity, and/or cost effectiveness.

Biological Patterns For Diagnosis And Treatment Of Cancer
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US Patent:

20050244973, Nov 3, 2005
Filed:

May 14, 2004
Appl. No.:

10/845773
Inventors:

Frank Andel - Berkeley CA, US
Hans Bitter - San Francisco CA, US
Mikhail Belov - Burlingame CA, US
Michael Brown - San Francisco CA, US
Alfred Greenquist - San Jose CA, US
Jonathan Heller - San Francisco CA, US
Alexander Sassi - Berkeley CA, US
John Stults - Redwood City CA, US
Kathy Stults - Redwood City CA, US
Assignee:

Predicant Biosciences, Inc. - South San Francisco CA
International Classification:

G01N033/48
US Classification:

436064000, 436173000
Abstract:

The present invention provides methods for diagnosing cancers, such as prostate cancer. Also, methods for evaluating the prostate cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry systems, antibody based techniques, or nucleic acid based techniques. The present invention also includes therapeutic and prophylactic agents that target the biomarkers described herein. Also, the present invention provides methods for the treatment of prostate cancer using the markers described herein or agents that mimic the properties of these markers.

Particle Fraction Determination Of A Sample
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US Patent:

20080297169, Dec 4, 2008
Filed:

May 31, 2007
Appl. No.:

11/756582
Inventors:

Alfred C. Greenquist - San Jose CA, US
Margaret McInerny - Monkstown, IE
International Classification:

G01N 33/86
B01J 19/00
G01N 27/06
G01N 27/07
US Classification:

324600, 422 681, 422 73, 422 8201, 436150, 436 69
Abstract:

The present invention provides a device, test cards, methods and kits which are useful for determining the particle fraction and rate of viscosity of a fluid sample, the presence of an analyte in a fluid sample, or the aggregation of particles in a fluid sample to detect an analyte or as an immunologic assay.

Systems And Methods For Discovery And Analysis Of Markers
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US Patent:

20110315552, Dec 29, 2011
Filed:

Feb 1, 2011
Appl. No.:

13/018622
Inventors:

John T. Stults - Redwood City CA, US
Alfred Greenquist - San Jose CA, US
Alexander Sassi - Berkeley CA, US
International Classification:

G01N 27/447
US Classification:

204450
Abstract:

A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.

Systems And Methods For Discovery And Analysis Of Markers
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US Patent:

20200041487, Feb 6, 2020
Filed:

Aug 22, 2019
Appl. No.:

16/548516
Inventors:

- South San Francisco CA, US
Alfred Greenquist - San Jose CA, US
Alexander Sassi - Berkeley CA, US
International Classification:

G01N 33/50
G16B 40/00
H01J 49/16
A61B 5/15
G01N 27/26
H01J 49/00
Abstract:

A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.

Systems And Methods For Discovery And Analysis Of Markers
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US Patent:

20190101527, Apr 4, 2019
Filed:

Sep 14, 2018
Appl. No.:

16/132076
Inventors:

- South San Francisco CA, US
Alfred Greenquist - San Jose CA, US
Alexander Sassi - Berkeley CA, US
International Classification:

G01N 33/50
H01J 49/00
G01N 27/26
H01J 49/16
G06F 19/24
Abstract:

A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.