Alexandre V Ivachtchenko

US Patent:

20100120792, May 13, 2010

Filed:

Apr 1, 2008

Appl. No.:

12/594453

Inventors:

Andrey Alexandrovich Ivashchenko - Moscow, RU
Alexandre Vasilievich Ivachtchenko - Encinitas CA, US
Sergey Yevgenievich Tkachenko - San Diego CA, US
Evgueni Borisovich Frolov - San Diego CA, US
Oleg Dmitrievich Mitkin - Moscow Region, RU
llya Matusovich Okun - San Diego CA, US
Nikolay Filippovich Savchuk - Rancho Santa Fe CA, US
Yan Lavrovsky - San Diego CA, US

International Classification:

A61K 31/4427
A61K 31/4745
C07D 471/04
A61P 25/08
A61P 25/18
A61P 25/28
A61P 25/24
A61P 25/22
A61P 9/10

US Classification:

51425505, 514292, 544405, 546 85, 546 87

Abstract:

The invention relates to antagonists of serotonin 5-HTreceptors simultaneously regulating homeostasis of Caions in cells, representing substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles of the general formula 1, pharmaceutically acceptable salts and/or hydrate thereof. In the general formula 1:Rrepresents amino group substituent selected from optionally substituted C-Calkyl; R, is one or more substituents selected from hydrogen, halogen, C-Calkyl, CF, OCF; Ar is phenyl optionally substituted with halogen, C-Calkyl, C-Calkoxy, substituted amino group, or CF; or optionally substituted aromatic 6-membered heterocycle comprising 1-2 nitrogen atoms in the cycle; W represents ethylene group —CH—CH—, ethenyl group —CH═CH—, or ethynyl group —C≡C—. The invention also relates to the novel compounds selected from the compounds of the general formula 1, methods for their preparation, pharmaceutical compositions and methods of their use.

US Patent:

20130196991, Aug 1, 2013

Filed:

Jul 19, 2011

Appl. No.:

13/811669

Inventors:

Alexandre Vasilievich Ivachtchenko - Encinitas CA, US
Oleg Dmitrievich Mitkin - Khimki, RU
Vadim Vasilievich Bichko - San Diego CA, US

Assignee:

Alla Chem, LLC - Carson City NV

International Classification:

C07D 487/06
C07D 413/14
C07D 401/14
C07D 401/06

US Classification:

5142352, 514250, 544364, 514323, 51425309

Abstract:

The invention relates to novel antiviral active components of the general formula 1, pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatisis C viruses (HCV). In the general formula 1

US Patent:

20130252992, Sep 26, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/831929

Inventors:

Alexandre Vasilievich IVACHTCHENKO - Encinitas CA, US
Oleg Dmitrievich MITKIN - Khimki, RU

International Classification:

C07D 233/86
C07D 471/10
C07D 491/107

US Classification:

514278, 514391

Abstract:

The present invention relates to novel cyclic N,N′-diarylurea-androgen receptor antagonist, anti-cancer agent, pharmaceutical composition, medicament, and method for treatment of breast cancer disease.Cyclic N,N′-diarylthioureas or N,N′-diarylureas of the general formula 1, their optical (R)- and (S)-isomers and pharmaceutically acceptable salts thereof exhibiting properties of androgen receptor antagonists have been proposed,

US Patent:

20130253008, Sep 26, 2013

Filed:

Nov 28, 2011

Appl. No.:

13/990428

Inventors:

Alexandre Vasilievich Ivachtchenko - Encinitas CA, US
Vadim Vasilievich Bichko - San Diego CA, US
Oleg Dmitrievich Mitkin - khimki, RU

Assignee:

Alla Chem LLC - Carson City NV

International Classification:

C07D 403/14
C07D 403/04
C07D 409/14
C07D 413/14
C07D 405/14

US Classification:

514316, 5483131, 514397, 548235, 514374, 546187, 5483147

Abstract:

The present invention relates to novel azoles, novel antiviral active components of the general formulas 1A and 1B, pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatitis C viruses (HCV). In general formulas 1A and 1Bwherein: solid lines with accompanying dotted lines () represent ordinary bond or double bond, provided that one of them is an ordinary bond, the other one is double bond; X and Y accept various meanings, one of them is—nitrogen, the other—oxygen, sulfur or NH group; Rand R—optionally the same radicals selected from 2-(R)- and (S)-substituted N-acyl pyrrolidine derivatives; N-methyl-N-[2-(R) and (S)-substituted 2,2-disubstituted acetamides; methyl[2-(R) and (S)-substituted ((methyl)amino)-(1-oxobutan-2-yl)-2-(R)-] and (S)-iso-propyl)-carbamates. A represents aliphatic C-Cbiradical; dioxane, cyclo- and bicycloaliphatic, alkyloxyalkyl, alkyloxyalkylenoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl biradicals and their thioanaloges; aryl and thiophene alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, alkyloxyaryl, alkenyloxyaryl, alkynyloxyaryl, alkylthioaryl, alkenylthioaryl, alkynylthioaryl, cycloalkylthiophene, aryldioxane and thiophenyldioxane biradicals. B represents: aliphatic C-Cradical, including 1, 2 or 3 triple C≡C bonds; aryl and thiophene, alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, cycloalkylbenzene, 4-cycloalkylbiphenyl, bicycloalkylbenzene, 4-bicycloalkylbiphenyl, cycloalkylthiophene, aryldioxane and thiophenyldioxane radicals.

US Patent:

20130267536, Oct 10, 2013

Filed:

Dec 13, 2011

Appl. No.:

13/993131

Inventors:

Alexandre Vasilievich Ivachtchenko - Encinitas CA, US
Oleg Dmitrievich Mitkin - Khimki, RU
Madina Georgievna Kadieva - Podosinki, RU

Assignee:

ALLA CHEM, LLC - Carson City NV

International Classification:

C07D 471/04
C07D 215/42
C07D 413/14
C07D 413/04
C07C 317/36
C07D 295/135
C07D 213/40

US Classification:

51425304, 51425307, 51425503, 514299, 514312, 514357, 514376, 514647, 544362, 544363, 544395, 544398, 546112, 546153, 546334, 548225, 564307

Abstract:

The present invention relates to novel substituted methyl-amines, serotonin 5-HTreceptor antagonists, to active components, pharmaceutical compositions, method for prophylaxis and treatment of CNS diseases and “molecular tools”, in which novel substituted methyl-amines represent compounds of the general formula 1 and their crystalline forms and pharmaceutically acceptable salts,wherein: W represents benzene, naphthalene, indolizine, quinoline or oxazole cycle; R1=H, F, Cl; R2 represents hydrogen, fluoro, methyl, phenyl, thienyl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 represents cyclopropyl or optionally substituted methyl; with the exception of the compounds in which W simultaneously represents oxazole cycle and R2=phenyl or pyridyl.

US Patent:

20130303609, Nov 14, 2013

Filed:

Apr 29, 2013

Appl. No.:

13/872174

Inventors:

Alexandre Vasilievich Ivachtchenko - Encinitas CA, US

Assignee:

ASAVI, LLC - Hallandale Beach FL

International Classification:

C07C 279/16

US Classification:

514529, 560 34, 435184

Abstract:

The present invention relates to novel neuraminidase activity inhibitors and use thereof for prophylaxis and treatment of influenza infection, that is to fluorosubstituted4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acids and their esters of the general formula 1, pharmaceutically acceptable salts and/or hydrates thereof,wherein R is hydrogen, an optionally substituted C-Calkyl, C-Calkenyl or C-Calkynyl; Rf is CHF or CHF.A pharmaceutical composition is provided, a method for its preparation, as well as a method for prophylaxis and treatment of viral diseases.

US Patent:

20220306625, Sep 29, 2022

Filed:

Mar 18, 2022

Appl. No.:

17/698956

Inventors:

- San Diego CA, US
Vladislav Zenonovich PARCHINSKY - Moscow, RU
Alexei PUSHECHNIKOV - San Diego CA, US
Alexandre Vasilievich IVACHTCHENKO - Hallandale Beach FL, US
Ruben ABAGYAN - La Jolla CA, US
Andrew ORRY - San Diego CA, US
Polo Chun-Hung LAM - San Diego CA, US
Nikolay SAVCHUK - San Diego CA, US

International Classification:

C07D 471/04
C07D 405/14
C07D 405/12
C07D 519/00
A61K 45/06

Abstract:

The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):

US Patent:

20220289745, Sep 15, 2022

Filed:

Mar 11, 2022

Appl. No.:

17/692923

Inventors:

- San Diego CA, US
Vladislav Zenonovich PARCHINSKY - Moscow, RU
Alexei PUSHECHNIKOV - San Diego CA, US
Alexandre Vasilievich IVACHTCHENKO - Hallandale Beach FL, US
Ruben ABAGYAN - La Jolla CA, US
Andrew ORRY - San Diego CA, US
Polo Chun-Hung LAM - San Diego CA, US
Nikolay SAVCHUK - San Diego CA, US

International Classification:

C07D 471/04

Abstract:

The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):