Alexander Jacob Varshavsky
age ~78
from Pasadena, CA
- Also known as:
-
- Alexander J Varshavsky
- Alexander J Varshavski
- Alex J Varshavsky
- Alexander Hawiger
- Phone and address:
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1474 Oakdale St, Pasadena, CA 91106
818 606-1908
Alexander Varshavsky Phones & Addresses
- 1474 Oakdale St, Pasadena, CA 91106 • 818 606-1908
- 1066 San Pasqual St APT 17, Pasadena, CA 91106
- Van Nuys, CA
- 5224 Escalante Dr, La Canada Flintridge, CA 91011
- La Canada, CA
- Boston, MA
- La Crescenta, CA
- 1474 Oakdale St, Pasadena, CA 91106
Work
-
Position:Professional/Technical
Education
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Degree:Graduate or professional degree
Industries
Biotechnology
Isbn (Books And Publications)
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The Harvey Lectures 2000-2001
view source -
Author:Alexander Varshavsky
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ISBN #:0471264660
Wikipedia References
Alexander Varshavsky
About:
Born:
1946
Work:
Alexander Varshavsky " Alexander Jacob Varshavsky " ( born 8 November 1946 ) is a Russian-American biochemist, noted for his discovery of the N-end rule of ubiquitination A native of Moscow, he is currently researching at Caltech....
Education:
Academic degree:
Member of the United States National Academy of Sciences
Specialty:Biochemist
Skills & Activities:
Ascribed status:
American of Russian descent
Award:Recipient of the Albert Lasker Award for Basic Medical Research • Prize
Preference:Murder
Amazon
The Harvey Lectures Series 96, 2000-2001
view sourceSeries 96, 2000—2001 covers themes in coordinated transcriptional regulation of cell growth and proliferation, cellular responses to telomere shortening, multicellular life in the plant kingdom, cell cycle control and cancer, and recent studies of the ubiquitin system and the N-end rule pathway.
Author
Harvey Society, Cornelia I. Bargmann, Robert N. Eisenman, Carol W. Greider, Richard D. Kolodner, Elliot M. Meyerowitz, Charles J. Sherr, Alexander Varshavsky
Binding
Hardcover
Pages
180
Publisher
Wiley-Liss
ISBN #
0471264660
EAN Code
9780471264668
ISBN #
5
Discovery of Cellular Regulation by Protein Degradation
view sourceBy revealing the fundamental and broad roles of the Ubiquitin system in cellular physiology, our biological studies of 1984–1990 produced the overall discovery of the physiological regulation by intracellular protein degradation. Ramifications of this advance became the beginnings of several biomedi...
Author
Alexander Varshavsky
Binding
Kindle Edition
Pages
58
ISBN #
1
New Classes of Conditional Toxins as Therapeutic Agents Against Breast Cancer
view sourceAuthor
Alexander Varshavsky
Binding
Paperback
Publisher
PN
ISBN #
4
Resumes
Professor Of Biology At Caltech
view sourceLocation:
Greater Los Angeles Area
Industry:
Biotechnology
Wikipedia
Alexander Varshavsky
view sourceAlexander Varshavsky is a Russian American biochemist and recipient of the Albert Lasker Award for Basic Medical Research, the Wolf Prize in Medicine and ...
Us Patents
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Modulation Of Nitric Oxide Signaling Through Signaling Through Specific Regulation By Arginylation And The N-End Rule Pathway
view source -
US Patent:7575881, Aug 18, 2009
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Filed:Sep 16, 2005
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Appl. No.:11/228157
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Inventors:Jun Sheng - Pasadena CA, US
Yong Tae Kwon - Wexford PA, US
Anna Kashina - Newtown Square PA, US
Alexander Varshavsky - La Canada CA, US -
Assignee:California Institute of Technology - Pasadena CA
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International Classification:G01N 33/53
G01N 33/573
C12Q 1/48 -
US Classification:435 721, 435 771, 435 772, 435 792, 435 793, 435 795, 435 8, 435 697, 435 698, 4352522, 4352528, 43525411, 530329, 530350
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Abstract:Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent that modulate the activity of the arginylation branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-end rule pathway mediated arginylation.
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Modulation Of Angiogenesis Through Targeting Of Arginyl Transferase (Ate1)
view source -
US Patent:7588901, Sep 15, 2009
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Filed:Jun 22, 2006
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Appl. No.:11/473568
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Inventors:Yong Tae Kwon - Wexford PA, US
Anna Kashina - Boca Raton FL, US
Alexander Varshavsky - La Canada CA, US -
Assignee:California Institute of Technology - Pasadena CA
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International Classification:G01N 33/53
G01N 33/573
G01N 33/533
G01N 33/535
C12Q 1/48
C12Q 1/02
C12N 9/10
C12N 15/54
C12N 15/81
C12N 11/16 -
US Classification:435 721, 435 771, 435 8, 435 15, 435 692, 435193, 4352523, 43525233, 43525411, 514 1
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Abstract:The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of N-terminal arginylation activity. The invention also provides a method of identifying such a modulator and a method of in vitro screening for modulators of N-terminal arginylation activity. Additionally, the invention provides a method of treating an angiogenesis-related disorder.
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Modulation Of Angiogenesis Through Targeting Of Arginyl Transferase (Ate1)
view source -
US Patent:20040009538, Jan 15, 2004
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Filed:Mar 21, 2003
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Appl. No.:10/394765
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Inventors:Yong Kwon - Wexford PA, US
Anna Kashina - Boca Raton FL, US
Alexander Varshavsky - La Canada CA, US -
International Classification:G01N033/53
G01N033/567
A61K031/00 -
US Classification:435/007200, 514/001000
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Abstract:The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of N-terminal arginylation activity. The invention also provides a method of identifying such a modulator and a method of in vitro screening for modulators of N-terminal arginylation activity. Additionally, the invention provides a method of treating an angiogenesis-related disorder.
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Modulation Of Angiogenesis Through Targeting Of Cysteine Oxygenase Activity
view source -
US Patent:20040023311, Feb 5, 2004
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Filed:Mar 21, 2003
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Appl. No.:10/395048
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Inventors:Yong Kwon - Wexford PA, US
Ilia Davydov - North Potomac MD, US
Fangyong Du - New Haven CT, US
Alexander Varshavsky - La Canada CA, US -
International Classification:G01N033/53
G01N033/567
A61K031/00 -
US Classification:435/007200, 514/001000
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Abstract:The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of N-terminal cysteine oxygenase activity. The invention also provides a method of identifying such a modulator and a method of in vitro screening for modulators of N-terminal cysteine oxygenase activity. Additionally, the invention provides a method of treating an angiogenesis-related disorder.
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Split- Ubiquitin Based Reporter Systems And Methods Of Their Use
view source -
US Patent:20040170970, Sep 2, 2004
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Filed:Aug 6, 2001
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Appl. No.:09/923917
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Inventors:Alexander Varshavsky - Flintridge CA, US
Sandra Wittke - Koeln, DE
Nils Johnsson - Koeln, DE
Norbert Lehming - Koeln, DE -
International Classification:C12Q001/68
C07H021/04
C12P021/04
C12N009/64 -
US Classification:435/006000, 435/069700, 435/226000, 435/320100, 435/325000, 536/023200
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Abstract:Methods and reagents for the detection and selection of two interacting-polypeptides, especially integral membrane proteins and transcription factors, by monitoring the reassembly of ubiquitin amino-terminal and carboxy-terminal chimeric polypeptide fragments are disclosed. Negative selection against an N-end rule-labilized marker released following ubiquitin reassembly allows direct selection of the interacting polypeptide pair. Methods to identify agonists and antagonists for certain protein-protein interactions; methods and reagents/kits for identifying proteins that binds a target protein are also provided. The dynamic and adaptable nature of the assay allows adaptation to a number of applications—such as probing the molecular environment of cellular membrane proteins in vivo.
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Targeting The Absence: Homozygous Dna Deletions As Signposts For Cancer Therapy
view source -
US Patent:20090018098, Jan 15, 2009
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Filed:Jul 11, 2008
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Appl. No.:12/172058
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Inventors:Alexander Varshavsky - La Canada CA, US
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Assignee:CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA
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International Classification:A61K 31/7088
C12P 21/04
C12Q 1/68
C12N 15/00 -
US Classification:514 44, 435 691, 4353201, 435 6
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Abstract:The present application relates to methods and compositions for targeting a homozygous DNA deletion (HD) in cells. Methods, structures, vectors and compositions for activating a payload in cells having an HD are provided. In some embodiments, the method comprises administering, to a population of cells comprising at least one cell having an HD, a nucleic acid vector encoding two complementary protein fusion molecules and a payload such that the payload is selectively activated only in cells having a HD. HDs are attractive “negative” targets for cancer therapy because of their immutability and prevalence in cancer cells. Thus, in some embodiments methods of treating cancer by specifically delivering a payload, such as a toxin, to cancer cells comprising one or more particular HDs are provided.
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Discovery And Applications Of The Proteolytic Function Of N-Terminal Acetylation Of Cellular Proteins
view source -
US Patent:20110230370, Sep 22, 2011
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Filed:Jan 14, 2011
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Appl. No.:13/007546
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Inventors:Anna Shemorry - Pasadena CA, US
Alexander Varshavsky - La Canada CA, US -
Assignee:CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA
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International Classification:C40B 30/08
C12Q 1/48
C07K 2/00
C12Q 1/66 -
US Classification:506 11, 435 15, 530300, 435 8
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Abstract:Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also provided are methods of using an agent that modulates the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway.
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Nucleic Acid Encoding Mammalian Ubr1
view source -
US Patent:58613129, Jan 19, 1999
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Filed:Dec 2, 1997
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Appl. No.:8/982956
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Inventors:Alexander Varshavsky - La Canada Flintridge CA
Yong Tae Kwon - Pasadena CA -
Assignee:California Institute of Technology - Pasadena CA
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International Classification:C12N 1512
C12N 1563
C12N 510
C12N 121 -
US Classification:435325
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Abstract:Disclosed here is a nucleic acid sequence encoding a recognition component of the N-end rule pathway. This nucleic acid sequence is characterized by the ability to specifically hybridize to the nucleic acid sequence of SEQ ID NO 1 under stringent hybridization conditions. Such conditions are defined below. Also disclosed is a nucleic acid sequence encoding a recognition component of the N-end rule pathway which is characterized by the ability to specifically hybridize to the nucleic acid sequence of SEQ ID NO 2 under stringent hybridization conditions. Also disclosed are DNA expression vectors containing nucleic acid sequences of the type described above, as well as cells transformed with such expression vectors. Further disclosed are applications for the compositions described above.
Mylife
Alex Varshavsky
view sourceLocality:
Chicago, IL
Alex Varshavsky
view sourceLocality:
San Francisco, CA
Alexander Varshavsky
view sourceLocality:
Wheeling, IL
Googleplus
Alexander Varshavsky
Alexander Varshavsky
Alexander Varshavsky
Alexander Varshavsky
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Youtube
News
Yuri Milner says he was not working for Russia to turn social media against US democracy
view source- the technology behind the television; Igor Sikorsky, who pioneered the helicopter; George Gamov, one of the key minds behind Big Bang theory; and brilliant contemporary scientists like the theoretical physicists Alexei Kitaev, Andrei Linde and Alexander Polyakov, or the biochemist Alexander Varshavsky
- Date: Nov 06, 2017
- Category: Top Stories
- Source: Google
Calif. biologist awarded $500K NY medical prize
view source- Alexander Varshavsky of the California Institute of Technology in Pasadena will receive the $500,000 Albany Medical Center Prize in Medicine and Biomedical Research in a May 21 ceremony. Medical center officials said Varshavsky was chosen in recognition of the seminal discoveries he made on intracel
- Date: Apr 15, 2014
- Category: Health
- Source: Google
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