Cynthia A. PANKER - Jessup MD, US Michael Ames Billard - Laurel MD, US Alan Ryan - Ellicott City MD, US Bindi Dangi - Elkridge MD, US
International Classification:
A61K 31/232 A61P 3/06
US Classification:
514549
Abstract:
The present invention is directed to an oral dosage form comprising a gel capsule comprising, (a) plasticizer; (b) gelatin; (c) water; and (d) greater than 850 mg DHA ethyl ester, wherein less than about 2% (wt/wt) of the total fatty acid content of the dosage form is EPA, wherein the total weight of the capsule is about 1 g and wherein the capsule is stable at about 25 C. at 60% relative humidity.
Compositions And Methods For Reducing Triglyceride Levels
Alan Stuart RYAN - Ellicott City MD, US Edward B. Nelson - Austin TX, US Jung Lee - McLean VA, US Krishna Raman - Wilmington DE, US
Assignee:
Martek Biosciences Corporation - Columbia MD
International Classification:
A61K 31/22 A61K 31/202 A61P 3/00
US Classification:
514549, 514560
Abstract:
The present invention is directed to methods of reducing plasma triglyceride level in subjects by administering docosahexaenoic acid (DHA). The method can comprise administering daily to the subject a dosage form comprising docosahexaenoic acid ester substantially free of eicosapentaenoic acid (EPA), wherein the DHA is derived from an algal source. In some embodiments, the method comprises administering daily to the subject a dosage form comprising DHA ester substantially free of EPA, wherein the DHA ester is about 60% to about 99.5% (w/w) of the total fatty acid content of the dosage form. In some embodiments, the method comprises administering daily to the subject a dosage form comprising about 200 mg to about 4 g of DHA ester substantially free of EPA. In some embodiments, the foregoing methods also result in a lowering of the amount of total cholesterol in the subject.
Martek Biosciences Corporation since Jan 2007
Executive Director, Clinical Research
Abbott Laboratories Aug 1983 - Jan 2007
Associate Research Fellow, Pharmaceutical Research and Development
Abbott Laboratories Jan 2000 - Jan 2006
Volwiler Associate Research Fellow
Pediatric Sales Support Jan 1999 - Jan 2000
Manager
Ross Products Division Jan 1997 - Jan 1999
Senior Group Leader
Education:
University of Michigan 1975 - 1980
PhD, Biological AnthropologyCompleted 2 years post-doctoral training at the Center for Human Growth and Development, University of Michigan. Expertise in epidemiology, statistics, nutrition, and growth and development
State University of New York at Binghamton 1968 - 1974
BA, Anthropology
University of Michigan
MA
Skills:
Clinical Trials Clinical Development Clinical Research Fda Pharmaceutical Industry Drug Development Cro Sop Gcp Nutrition Regulatory Affairs Biotechnology Medical Devices Clinical Monitoring Biochemistry Medical Writing Project Management Drug Discovery Laboratory Clinical Study Design Technology Transfer Gmp Lifesciences Infectious Diseases Epidemiology Validation Data Analysis Oncology Medicine Fatty Acids Omega 3 Fatty Acids Cardiovascular Disease Neuroscience Glp Preclinical Proof of Concept and Safety Studies For Gras Or Drugs Consulting Babies Science Manuscript Preparation Cardiovascular Research Ind and Nda Development Data Analyses Editing Gcps Sops Presentations Team Leader Infant Formula Orphan Drug Development Developed Key Opinion Leader Relationships
Interests:
Model Railroading Children Motorcycle Riding Ballroom Dancing Science and Technology Travel Health
2008 to 2000 Executive DirectorEssentient Inc Cambridge, MA Jan 2012 to Apr 2012 Senior Director, Preclinical and Clinical ResearchMartek Biosciences Corporation Columbia, MD 2006 to 2008 Executive Director of Clinical ResearchPharmaceutical R&D, Abbott Laboratories
2000 to 2006 Volwiler Associate Research FellowAbbott Laboratories Columbus, OH 1999 to 2000 Manager, Pediatric Sales SupportAbbott Laboratories
1997 to 1999 Senior Group Leader, Ross Products DivisionAbbott Laboratories
1994 to 1997 Group Leader, Ross Products DivisionAbbott Laboratories
1991 to 1994 Senior Clinical Research Associate, Ross Products DivisionMarketing Research Nutrition Services, Ross Products Division, Abbott Laboratories
1986 to 1991 ManagerAbbott Laboratories
1983 to 1986 Marketing Research Associate, Ross Products Division
Education:
University of Michigan 1980 PhD in Biological Anthropology, NutritionUniversity of Michigan 1977 MA in Biological Anthropology