Alan Douglas Kinghorn

US Patent:

6737439, May 18, 2004

Filed:

Jul 25, 2002

Appl. No.:

10/205029

Inventors:

Alan Douglas Kinghorn - Chicago IL
John M. Pezzuto - River Forest IL
Dongho Lee - Chicago IL
Krishna P. L. Bhat - Chicago IL

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K 3135

US Classification:

514455, 514456, 514457, 549387, 549400, 549401

Abstract:

A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of , or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammals, including humans.

US Patent:

20090181110, Jul 16, 2009

Filed:

Jul 9, 2008

Appl. No.:

12/169858

Inventors:

Marcy J. Balunas - Indicasat, PA
Bin Su - Glendora CA, US
Robert W. Brueggemeier - Columbus OH, US
Alan Douglas Kinghorn - Columbus OH, US

Assignee:

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH

International Classification:

A61K 36/38
C12N 9/99
A61K 31/352
C12N 9/00
A61P 35/00

US Classification:

424725, 435184, 514455, 435 4

Abstract:

Aromatase inhibitors (AIs) are disclosed which are useful in the treatment and prevention of post-menopausal breast cancer. New AIs derived from natural products are disclosed that are evaluated for clinical utility for treating post-menopausal breast cancer and may also act as chemopreventive agents for preventing breast cancer. Several pure compounds demonstrated AI activity using a noncellular, enzyme-based microsomal and a cell-based aromatase assay. Correlations are made between structural classes with levels of aromatase inhibition. The disclosure may be utilized to direct synthetic modification of natural product scaffolds to enhance aromatase inhibition or to standardize botanical dietary supplements for increased aromatase inhibition activity.

US Patent:

48084093, Feb 28, 1989

Filed:

Aug 16, 1984

Appl. No.:

6/641526

Inventors:

Alan D. Kinghorn - Chicago IL
Cesar M. Compadre - Chicago IL
John M. Pezzuto - Glen Ellyn IL

Assignee:

Board of Trustees, University of Illinois - Urbana IL

International Classification:

A61K 716
C07C 49713

US Classification:

424439

Abstract:

Racemic hernandulcin, a sesquiterpene, possesses a sweetness intensity about three orders of magnitude greater than that of sucrose. It is non-mutagenic and non-toxic under conventional assay procedures. In addition to attractive utility in foods, beverages and pharmaceutical compositions, it affords a low-cariogenic, essentially non-nutritive sweetening agent for inclusion in oral hygiene products.

US Patent:

44683286, Aug 28, 1984

Filed:

Jan 17, 1983

Appl. No.:

6/435070

Inventors:

Alan D. Kinghorn - Chicago IL
Gary T. Marshall - Chicago IL

Assignee:

The Board of Trustees of the University of Ill. - Urbana IL

International Classification:

B01D 1508

US Classification:

210634

Abstract:

Droplet counter-current chromatography is utilized to isolate and purify 12-O-tetradecanoylphorbol-13-acetate (TPA), phorbol, and the diastereoisomer 4. alpha. -phorbol from croton oil. The stationary and mobile phases for the procedure are derived from an equilibrated mixture of hexane-diethylether-n-propanol-ethanol-water, the separated upper layer of which comprises the stationary phase and the bottom layer of which the mobile phase. The TPA and the phorbol isomers are obtained in exceptionally high purity by further treatment with liquid column chromatography and thin-layer chromatography.

US Patent:

20200197514, Jun 25, 2020

Filed:

Aug 24, 2018

Appl. No.:

16/641417

Inventors:

- Columbus OH, US
James R. FUCHS - Columbus OH, US
Alan Douglas KINGHORN - Columbus OH, US
Li PAN - Rockton IL, US
Eric BACHELDER - Dublin OH, US
Narasimham L. PARINANDI - Upper Arlington OH, US

International Classification:

A61K 39/39
A61K 31/575
A61K 45/06
A61K 39/008

Abstract:

Disclosed herein are methods of using immunomodulatory sterols as vaccine adjuvants. Accordingly, certain embodiments relates to pharmaceutical compositions containing at least one antigen and at least one immunomodulatory sterol; and, methods of inducing an immunomodulatory response in a patient by administering an immunomodulatory-effective amount of at least one immunomodulatory sterol.

US Patent:

20190054105, Feb 21, 2019

Filed:

Apr 26, 2017

Appl. No.:

16/079754

Inventors:

- Columbus OH, US
Alan Douglas KINGHORN - Columbus OH, US
Andrew HUNTSMAN - Fort Jennings OH, US

International Classification:

A61K 31/7048
A61K 45/06
A61K 31/365
A61P 35/00

Abstract:

Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.

US Patent:

20170305959, Oct 26, 2017

Filed:

Jan 20, 2017

Appl. No.:

15/411249

Inventors:

- Columbus OH, US
James F. Fuchs - Columbus OH, US
Alan Douglas Kinghorn - Columbus OH, US
Li Pan - Upper Arlington OH, US
Eric Bachelder - Dublin OH, US

International Classification:

C07J 9/00
A61K 9/00
A61K 47/40
A61K 47/34
A61K 45/06
A61K 31/575
A61K 31/57
A61K 9/51
A61K 9/20
A61K 9/20
A61K 9/20
A61K 9/16
A61K 9/127
A61K 9/127
A61K 9/107
A61K 9/10
A61K 47/44
C07J 7/00

Abstract:

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from . This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20140287030, Sep 25, 2014

Filed:

Jun 9, 2014

Appl. No.:

14/300191

Inventors:

Abhay R. Satoskar - Upper Arlington OH, US
James R. Fuchs - Columbus OH, US
Alan Douglas Kinghorn - Columbus OH, US
Li Pan - Upper Arlington OH, US
Eric Bachelder - Dublin OH, US

Assignee:

OHIO STATE INNOVATION FOUNDATION - Columbus OH

International Classification:

C07J 9/00
A61K 31/57
C07J 7/00
A61K 31/575
A61K 45/06

US Classification:

424450, 514177, 514171, 514182, 514179

Abstract:

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from . This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.