Aiping Dang Yujing Bai from 1630 Pin Oak Cut, Mount Pleasant, SC 29466, age 52, Phone: 843 568-9780

Lysosomotropic Inhibitors Of Acid Ceramidase
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US Patent:

20110251197, Oct 13, 2011
Filed:

Nov 6, 2009
Appl. No.:

13/127888
Inventors:

Alicja Bielawska - Charleston SC, US
Aiping Bai - Charleston SC, US
Zdzislaw M. Szulc - Charleston SC, US
Yusef A. Hannun - Sullivan's Island SC, US
James Norris - Mount Pleasant SC, US
Liu Xiang - Mount Pleasant SC, US
International Classification:

A61K 31/5375
C07D 233/64
C07D 295/15
C07C 237/20
A61K 31/4164
A61K 31/165
C07C 233/47
A61K 31/216
A61P 35/00
A61P 35/04
A61P 9/00
A61P 9/10
A61P 29/00
A61P 11/06
A61P 17/00
C12N 9/99
US Classification:

5142382, 435184, 5483381, 544167, 554 60, 564196, 514399, 514626, 560173, 560171, 514551, 514548
Abstract:

The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.

Site And Rate Selective Prodrug Formulations Of D609 With Antioxidant And Anticancer Activity
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US Patent:

20070244076, Oct 18, 2007
Filed:

Oct 8, 2004
Appl. No.:

10/575188
Inventors:

G. Meier - Pullman WA, US
Aiping Bai - Charleston SC, US
Daohong Zhou - Mt. Pleasant SC, US
Assignee:

MUSC Foundation Research Development - Charleston SC
International Classification:

A61K 31/66
A61K 31/265
C07F 9/06
US Classification:

514127000, 514512000, 558231000
Abstract:

Compounds that are heteroatom substituted alkyl derivatives of tricyclodecan-9-yl-xanthogenate, and pharmaceutical compositions of these compounds, are disclosed. Methods of treating a disease or disorder in a subject and methods of protecting normal tissues in a subject from toxicity associated ionizing radiation or chemotherapy using compositions comprising these novel compounds are also disclosed. The invention also concerns methods of treating a disease or disorder in a subject using compositions that include these novel compounds while concurrently or consecutively treating the subject with ionizing radiation or a chemotherapeutic agent.