Described herein are gold particles that can be used to reduce tumor proliferation and treat cancer. In certain aspects, the gold particles can be modified in order to enhance selectivity and uptake of the particles by cancer cells. In certain aspects, the modified gold particles have a targeting group attached to the particle via a linker. The gold particles described herein can be used in combination with other anti-cancer agents in order to enhance overall cancer treatment. Methods for making and using the gold particles are also described herein.
Vivo Radical-Mediated Polymerization For Targeted Delivery Of Trophic Factors
- New Brunswick NJ, US David I. Shreiber - Whitehouse Station NJ, US Emily DiMartini - Brick Township NJ, US Adam Gormley - New Brunswick NJ, US
Assignee:
Rutgers, The State University of New Jersey - New Brunswick NJ
International Classification:
A61K 47/69 A61K 47/34 A61K 47/10 C08L 33/06
Abstract:
The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury.
In Vivo Radical-Mediated Polymerization For Targeted Delivery Of Trophic Factors
The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury.