Adam H Amsterdam

US Patent:

20040142440, Jul 22, 2004

Filed:

Aug 6, 2003

Appl. No.:

10/635145

Inventors:

Nancy Hopkins - Cambridge MA, US
Adam Amsterdam - Cambridge MA, US
Eric Swindell - Sugar Land TX, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12Q001/68
C07H021/04
C12N009/10

US Classification:

435/193000, 435/069100, 435/320100, 435/325000, 536/023200, 435/006000

Abstract:

Novel seryl transfer RNA polynucleotides and polypeptides, as well as methods of using such polynucleotides and polypeptides for the identification of therapeutic compounds are disclosed. Also disclosed are zebrafish that have a mutation in a seryl transfer RNA gene.

US Patent:

20040068763, Apr 8, 2004

Filed:

Mar 28, 2003

Appl. No.:

10/403571

Inventors:

Nancy Hopkins - Cambridge MA, US
Gregory Golling - Beaverton OR, US
Adam Amsterdam - Cambridge MA, US

International Classification:

A01K067/027

US Classification:

800/020000

Abstract:

The invention features novel zebrafish nucleic acid and amino acid molecules, and zebrafish containing mutations in important developmental genes. In addition, the invention features the use of these nucleic acid and amino acid molecules in methods of diagnosing, preventing, and treating a variety of mammalian diseases and developmental disorders. Furthermore, zebrafish mutant for a nucleic acid or amino acid molecule of the invention may be used in screens for compounds that modulate the development of an organism as a whole or of specific tissues or organs within an organism. In particular, the present invention features novel nucleic acid sequences involved, e.g., in kidney development and kidney disorders. Mutations in these sequences, for example, result in the formation of cysts in the kidney.