Abraham B Spector from 808 Broadway, New York, NY 10003, age 99, Phone: 212 260-0311

Name / Title

Company / Classification

Phones & Addresses

Abraham Spector
Owner

Spector, Abraham Law Offices of
Legal Services Office

26 Ct St, Brooklyn, NY 11242
185 Montague St, Brooklyn, NY 11201
718 875-3900

Compounds Having Glutathione Peroxidase Activity And Use Thereof
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US Patent:

53211383, Jun 14, 1994
Filed:

Apr 29, 1991
Appl. No.:

7/692931
Inventors:

Abraham Spector - New York NY
Stephen R. Wilson - Chatham NJ
Paul A. Zucker - Maplewood NJ
Assignee:

The Trustees of Columbia University in the City of New York - New York NY
New York University - New York NY
International Classification:

C07C 3702
A01K 31095
US Classification:

546224
Abstract:

The present invention provides compounds having glutathione peroxidase activity and, therefore, are effective glutathione peroxidase replacements. These compounds are useful as drugs for the prevention of cataracts and as anti-oxidants for H. sub. 2 O. sub. 2 and other peroxides. The present invention also provides methods and pharmaceutical compositions of the compound.

Use Of Heme-Peptides To Prevent Or Retard Disease Associated With Oxidative Stress
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US Patent:

60136235, Jan 11, 2000
Filed:

Feb 27, 1997
Appl. No.:

8/807482
Inventors:

Abraham Spector - New York NY
Wanchao Ma - New York NY
Assignee:

The Trustees of Columbia University in the City of New York - New York NY
International Classification:

A61K 3800
A61K 3816
C07K 500
C07K 700
US Classification:

514 6
Abstract:

This invention provides a method for treating a condition associated with oxidative stress in a subject which comprises administering to the subject an amount of a heme-peptide effective to treat the condition associated with oxidative stress in the subject. The subject may be a mammal. The mammal may be a human being. The condition associated with oxidative stress may be an inflammatory condition, an allergic condition or an auto-immune condition.

Compounds Having Glutathione Peroxidase Activity And Use Thereof
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US Patent:

51283654, Jul 7, 1992
Filed:

Jul 19, 1989
Appl. No.:

7/383189
Inventors:

Abraham Spector - New York NY
Stephen R. Wilson - Chatham NJ
Paul A. Zucker - Maplewood NJ
Assignee:

The Trustees of Columbia University in the City of New York - New York NY
New York University - New York NY
International Classification:

C07C40312
C07D31902
A61K 3140
A61K 31095
US Classification:

514422
Abstract:

The present invention provides compounds having glutathione peroxidase activity and, therefore, are effective glutathione peroxidase replacements. These compounds are useful as drugs for the prevention of cataracts and as anti-oxidants for H. sub. 2 O. sub. 2 and other peroxides. The present invention also provides methods and pharmaceutical compositions of the compound.

Method And Ophthalmic Composition For The Prevention And Reversal Of Cataracts
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US Patent:

47710365, Sep 13, 1988
Filed:

Feb 10, 1986
Appl. No.:

6/828112
Inventors:

Vincent P. Pigiet - Winchester MA
Abraham Spector - New York NY
Assignee:

Trustees of Columbia University in the city of New York - New York NY
International Classification:

A61K 3702
US Classification:

514 17
Abstract:

The subject invention concerns a process for the prevention and reversal of cataracts. Specifically, the invention comprises the treatment of the eye lens with an effective cataract inhibiting amount of thioredoxin or thioredoxin-derived, or thioredoxin-like, dithiol peptide, alone, or in combination with a thioredoxin reductase regenerating system. The thioredoxin compound can be administered topically to a patient in need of such treatment on a daily basis over an extended period of time via known delivery techniques such as eye drops and ocular inserts.